%0 Journal Article
%T Castor oil polyurethane containing silica nanoparticles as filling material of bone defect in rats
%A Nacer
%A Renato Silva
%A Poppi
%A Rodrigo R¨¦
%A Carvalho
%A Paulo de Tarso Camilo de
%A Silva
%A Baldomero Antonio Kato da
%A Odashiro
%A Alexandre Nakao
%A Silva
%A Iandara Schettert
%A Delben
%A Jos¨¦ Renato Jurkevicz
%A Delben
%A Angela Antonia Sanches Tardivo
%J Acta Cirurgica Brasileira
%D 2012
%I Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
%R 10.1590/S0102-86502012000100010
%X purpose: to evaluate the biologic behavior of the castor polymer containing silica nanoparticles as a bone substitute in diafisary defect. methods: twenty seven male rattus norvegicus albinus wistar lineage were submitted to bone defect filled with castor oil polymer. three experimental groups had been formed with nine animals each: (1) castor oil polymer containing only calcium carbonate; (2) castor oil polymer with calcium carbonate and doped with 5% of silica nanoparticles; (3) castor polymer with calcium carbonate doped with 10% of silica nanoparticles; 3 animals of each group were submitted to euthanasia 15, 30 and 60 days after experimental procedure, and their femurs were removed to histological evaluation. results: there was bone growth in all the studied groups, with a greater tendency of growth in the group 1. after 30 days all the groups presented similar results. after 60 days a greater amount of fibroblasts, osteoblasts, osteocytes and osteoclasts in group 3 was observed, with integrated activity of 3 kinds of cells involved in the bone activation-reabsorption-formation. conclusions: the castor polymer associated to the silica nanoparticles is biocompatible and allows osteoconduction. the presence of osteoprogenitors cells suggests silica osteoinduction capacity.
%K biocompatible materials
%K bone substitutes
%K castor oil
%K rats.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0102-86502012000100010&lng=en&nrm=iso&tlng=en