%0 Journal Article
%T Efecto del Prop¨®leos Chileno sobre el Metabolismo de Glucosa en Ratones Diab¨¦ticos
%A Pacheco
%A Alejandro
%A Daleprane
%A Julio B
%A Freitas
%A Vanessa S
%A Ferderbar
%A Simone
%A Hirabara
%A Sandro
%A Cuevas
%A Alejandro
%A Saavedra
%A Nicol¨˘s
%A Curi
%A Rui
%A Abdalla
%A Dulcineia S. P
%A Salazar
%A Luis A
%J International Journal of Morphology
%D 2011
%I Scientific Electronic Library Online
%R 10.4067/S0717-95022011000300015
%X in the current study, we investigated the effect of propolis on diabetic mice undergoing propolis treatment (150 mg/kg/day) for a 6 week period. we also evaluated serum lipids, glucose, insulin levels and the effect on glucose uptake of 2-deoxy-d-[2,6-3h] glucose, [14c]-glycogen synthesis and [u-14c]-d-glucose decarboxylation induced by insulin in muscle tissue. our results show that treatment with propolis (150 mg/kg/day) reduced insulin and homa index (p<0.05). propolis also lowered abdominal obesity (p<0.05). no effects over serum glucose, total cholesterol and triglycerides levels were observed. we also observed that uptake of 2-deoxy-d-[2,6-3h] glucose, [14c]-glycogen synthesis and [u-14c]-d-glucose decarboxylation induced by insulin in soleus muscle of mice treated with propolis were significantly greater than control group (p<0.05). in summary, our data establishes that propolis modulates glucose metabolism. this result constitutes important data indicating that propolis can be used as a polyphenols source with antidiabetogenic activity.
%K propolis
%K diabetic mice
%K polyphenols
%K glucose.
%U http://www.scielo.cl/scielo.php?script=sci_abstract&pid=S0717-95022011000300015&lng=en&nrm=iso&tlng=en