%0 Journal Article
%T Neonatal treatment with clomipramine and depression: A review of behavioral and physiological findings
%A Justel
%A Nadia
%A Bentosela
%A Mariana
%A Mustaca
%A Alba
%A Ruetti
%A Eliana
%J Interdisciplinaria
%D 2011
%I Scientific Electronic Library Online
%X many times in science, the discovery of a treatment that has certain effect happens accidentally while the scientists are investigating another phenomenon. this is the case of the discovery of a possible animal model of depression by the administration of clomipramine (cli) during neonatal days. adult animals exposed to cli in neonatal days showed alterations in rem sleep (for example, the decrease of rem latency); lower weight, disruptions in locomotor activity (the increase in activity depend on the dark / light phase in which the test starts, when the animals were tested in the light phase they found increase in activity, but no changes were observed when the animals were tested in the dark phase); less intracraneal self-stimulation, lower saccharin and sucrose consumption, less suppression of the consummatory behavior, sexual alterations in males (for example, expressed as a lower number of mounts and ejaculations; no alterations were found in the activity of the hypothalamic - pituitary - gonadal axis and the level of testosterone was normal), higher alcohol consumption, disruptions in the agonistic response (cli - treated animals were significantly less aggressive than control groups) and in learning (in the passive avoidance task and 8 radial arm maze) compared to untreated animals (rats that received vehicle during neonatal days). several of these abnormalities could be reversed with those treatments that are effective for treating depression in humans (antidepressive drugs, nicotine and rem sleep deprivation treatment). these results were obtained in male rats of different strains and in hamsters, and at different months, the majority of them at 3-4 months, and some of them after the sixth, this could be because some changes were caused with the decrement in the age of the animals, although further research is needed to elucidate this issue. neuroendocrinal alterations analogous to those found in human depression were also discovered in cli - treated rats,
%K depression
%K clomipramine
%K neonatal treatment
%K rats.
%U http://www.scielo.org.ar/scielo.php?script=sci_abstract&pid=S1668-70272011000200003&lng=en&nrm=iso&tlng=en