%0 Journal Article
%T Descondensaci¨®n de la heterocromatina en bovinos criollos portadores de la translocaci¨®n Robertsoniana (rob1; 29). Acci¨®n del inductor 5-azacitidina-C
%A Artigas
%A Rody
%A Iriarte
%A Wanda
%A de Soto
%A Leticia
%A Iriarte
%A Andr¨¦s
%A Llamb¨ª
%A Silvia
%A de Bethencourt
%A Miguel
%A Postiglioni
%A Alicia
%J Acta Agron¨®mica
%D 2008
%I Universidad Nacional de Colombia Sede Palmira
%X the robertsonian translocation (rob1; 29) is widely spread in commercial breeds and specially in genetic reserve of american creole cattle. it is also described a delay on embryo development in front of normal ones. the action of 5-aza-c, as an hypomethylated agent, could permitted to decondensate the constitutive or facultative heterochromatin. in this work we made induction with the 5-aza-c(10mm, 2 hrs) analogs, in lymphocyte cultures of female and male carriers and normal creole cattle. the dna hypometilation is found in the inactive x chromosome of late replication as it is incorporated during the last hours of cell culture. the decondensing effects of 5-aza-c analogs is observed in multiple regions of the autosomes chromatin, the rob1; 29 and the bta1. a correlation between hypometilated regions and decondensed of facultative (conditional) heterochromatin is related with genomic instability, and epigenetic reprogramming.
%K 5-azacytidine-c
%K decondensation
%K rob1
%K 29
%K creole cattle.
%U http://www.scielo.org.co/scielo.php?script=sci_abstract&pid=S0120-28122008000100010&lng=en&nrm=iso&tlng=en