%0 Journal Article
%T Research Progress of Polyphenolic Antioxidants in Disease Therapy: Molecular Mechanisms and Clinical Applications
%A Luhong Yang
%A Yaqi Guo
%A Wenhui Cheng
%A Yuchong Li
%A Hongwei Bai
%A Wei Chen
%A Huafeng Wang
%J Open Access Library Journal
%V 13
%N 5
%P 1-21
%@ 2333-9721
%D 2026
%I Open Access Library
%R 10.4236/oalib.1115302
%X Polyphenolic antioxidants are a diverse class of plant-derived secondary metabolites ubiquitously found in plant-based foods, highly promising for therapeutic intervention of various diseases. This review systematically co-vers dietary polyphenols from common food sources, purified compounds, polyphenol-rich plant extracts, and emerging delivery systems for bioavaila-bility enhancement, with a core focus on their molecular mechanisms of ac-tion and therapeutic potential in neurodegenerative diseases, cardiovascular diseases, and malignancies. The review details diverse molecular mecha-nisms underpinning polyphenol efficacy, extending beyond direct antioxidant activity to include modulation of signaling pathways, enzyme inhibition, and gene expression regulation. Evidence demonstrates their potential in miti-gating oxidative stress, inflammation, and specific pathological processes characteristic of Alzheimer¡¯s disease, Parkinson¡¯s disease, atherosclerosis, hypertension, and various cancers. However, significant challenges in phar-macokinetics, particularly poor bioavailability and extensive metabolism, hinder clinical translation. While preclinical evidence is compelling, over-coming bioavailability limitations via novel delivery systems or structural optimization is crucial for clinical advancement.
%K Antioxidants
%K Cancer
%K Cardiovascular Diseases
%K Neurodegenerative Diseases
%K Polyphenols
%U http://www.oalib.com/paper/6894777