%0 Journal Article
%T When the Mouth Speaks First: Isolated Oral Pemphigus Vulgaris¡ªA Case Report and Literature Review
%A Salma Azizi Alaoui
%A Wafaa Mahfoud
%A Kaoutar El Khalifa
%A Lamia Kissi
%J Open Access Library Journal
%V 13
%N 3
%P 1-10
%@ 2333-9721
%D 2026
%I Open Access Library
%R 10.4236/oalib.1115068
%X <strong>Background:</strong> Pemphigus vulgaris (PV) is a rare autoimmune blistering disease in which oral lesions often precede cutaneous involvement. Early diagnosis may be delayed because of nonspecific presentations. <strong>Case Presentation:</strong> A 28-year-old woman presented with a one-year history of painful oral bullae and erosions without skin lesions. Clinical examination revealed multifocal erosions and a positive Nikolsky¡¯s sign. Histopathology demon-strated suprabasal clefting, acantholysis, and a ¡°tombstone¡± basal layer, confirming PV. Systemic prednisone (60 mg/day) resulted in significant improvement within 10 days. Persistent inflammation related to impacted mandibular third molars was addressed surgically. By day 40, oral lesions had fully resolved; however, new-onset dysphagia raised concern for pharyngeal or esophageal involvement, necessitating referral to internal medicine. <strong>Conclusion:</strong> This case underscores the importance of early biopsy, recognition of local inflammatory triggers, and coordinated multidisciplinary care in isolated oral PV to prevent disease progression.<br />
%K Pemphigus Vulgaris
%K Mouth Mucosa
%K Stomatitis
%K Autoimmune Diseases
%K Corticosteroids
%K Acantholysis
%K Immunofluorescence
%K Tooth Extraction
%U http://www.oalib.com/paper/6891032