%0 Journal Article %T A Comprehensive Approach to Preventing Tauopathy and Enhancing Learning and Memory through Neurotrophic Factor Induction with Cistanche tubulosa Extract %A Chin-Tsai Chou %A Chao-Jih Wang %A Bo-Kai Wu %A Chang-Jen Huang %A Muh-Hwan Su %J Open Access Library Journal %V 13 %N 2 %P 1-14 %@ 2333-9721 %D 2026 %I Open Access Library %R 10.4236/oalib.1114783 %X The neuroprotective efficacy and safety of Cistanche tubulosa extract (CTE) in reducing tauopathy levels were studied. However, evidence-based insights into how CTE enhances memory ability remain unclear. A total of 85 healthy volunteers (with MMSE scores ¡Ý 24, which is Normal/No impairment) participated in a double-blind, randomized, placebo-controlled study. Participants were assigned to one of three groups: Group A (600 mg CTE), Group B (300 mg CTE), or Group C (placebo), administered once daily for six weeks. Efficacy was assessed using the clinical memory scale, along with measurements of brain-derived neurotrophic factor (BDNF) and acetylcholinesterase (AChE) concentrations. Results showed statistically significant changes in BDNF and AChE levels in both treatment groups (Groups A and B) compared to baseline and the placebo group. Memory tests also demonstrated significant improvements (p < 0.01) in summary test scores in Groups A and B compared to Group C after six weeks. Additionally, we utilized the Tol2 transposon-mediated gene transfer method to generate transgenic zebrafish expressing tau-GFP (green fluorescent protein), and employed CTE compounds (echinacoside, acteoside, and isoacteoside) to screen for anti-secretase enzyme activity. Results from transgenic fluorescent triple-transgenic (3xTg-AD) zebrafish demonstrated that CTE exhibits anti-tauopathy, anti-secretase, and neuroprotective properties. These findings, combined with the above evidence, confirm that CTE has potential neuroprotective effects and may improve memory function.  %K Neurotrophic %K Cistanche Tubulosa %K Memory %K BDNF %K Transgenic Zebrafish %K Anti-Secretase %U http://www.oalib.com/paper/6883725