%0 Journal Article
%T 骨髓增生异常综合征与信号通路关系的文献综述<br>A Literature Review on the Relationship between Myelodysplastic Syndromes and Signaling Pathways
%A 杨婷婷
%A 张家帅
%A 郝晶
%J Advances in Clinical Medicine
%P 1907-1913
%@ 2161-8720
%D 2025
%I Hans Publishing
%R 10.12677/acm.2025.1561930
%X 骨髓增生异常综合征(MDS)是一组异质性的造血干细胞克隆性疾病&#65292;其特征是骨髓发育异常和无效造血&#65292;导致外周血细胞减少。这种疾病具有转变为急性髓细胞性白血病(AML)的风险&#65292;现有的治疗方案并不能满足MDS患者的生存和预后等问题。研究发现JAK-STAT等信号通路在MDS的发生发展过程中起到重要作用。本文对多条信号通路在MDS中作用机制的研究进展进行综述。<br>Myelodysplastic Syndromes (MDS) are a group of heterogeneous clonal disorders of hematopoietic stem cells, characterized by abnormal marrow development and ineffective hematopoiesis, leading to reduced peripheral blood cells. This disease carries a risk of transformation into acute myeloid leukemia (AML), and existing treatment options do not sufficiently address the survival and prognostic concerns of MDS patients. Research has identified the JAK-STAT signaling pathway, among others, as playing a significant role in the development and progression of MDS. This article reviews the research progress on the mechanisms of action of multiple signaling pathways in MDS.
%K 骨髓增生异常综合征&#65292
%K SF3b1&#65292
%K 信号通路<br>Myelodysplastic Syndromes
%K SF3b1
%K Signaling Pathway
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=118557