%0 Journal Article
%T 戈米辛N治疗自身免疫性肝炎的机制研究<br>Research on the Mechanism of Gomisun N in the Treatment of Autoimmune Hepatitis
%A 张成
%A 李红艳
%A 齐高林
%A 杨子杰
%J Medical Diagnosis
%P 319-328
%@ 2164-5418
%D 2025
%I Hans Publishing
%R 10.12677/md.2025.153043
%X 自身免疫性肝炎是一种以肝脏炎症为特征的慢性疾病&#65292;主要由机体免疫系统错误地攻击自身肝细胞引起。该疾病的发病率在不同人群中有所差异&#65292;尤其在女性中更为常见&#65292;且其临床表现多样&#65292;包括乏力、黄疸、腹痛等&#65292;严重时可导致肝衰竭。尽管目前已有多种治疗方法&#65292;如免疫抑制剂和肝移植&#65292;但仍存在疗效不佳和副作用等问题。因此&#65292;寻找新的治疗策略显得尤为重要。戈米辛N是一种从植物中提取的生物活性成分&#65292;近年来的研究表明其具有显著的抗炎作用&#65292;能够通过调节免疫反应来减轻炎症。因此&#65292;本研究旨在探讨戈米辛N预给药对刀豆蛋白诱导的小鼠自身免疫性肝炎模型中炎症反应的影响。<br>Autoimmune hepatitis is a chronic disease characterized by inflammation of the liver, primarily caused by the immune system mistakenly attacking its own liver cells. The incidence of this disease varies among different populations, being more common in women, and its clinical manifestations are diverse, including fatigue, jaundice, and abdominal pain, which can lead to liver failure in severe cases. Although there are various treatment methods available, such as immunosuppressants and liver transplantation, issues like poor efficacy and side effects still exist. Therefore, finding new treatment strategies is particularly important. Gomisinin N is a bioactive component extracted from plants, and recent studies have shown that it has significant anti-inflammatory effects, capable of alleviating inflammation by regulating immune responses. Thus, this study aims to explore the effects of Gomisinin N pre-treatment on the inflammatory response in a mouse model of autoimmune hepatitis induced by concanavalin A.
%K 自身免疫性肝炎&#65292
%K 戈米辛N&#65292
%K 炎症因子&#65292
%K 刀豆蛋白A<br>Autoimmune Hepatitis
%K Gomisun N
%K Inflammatory Factors
%K Concanavalin A
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=118375