%0 Journal Article
%T Electrical and Echocardiographic Abnormalities in Sickle Cell Disease Followed up at the National Sickle Cell Disease Reference Centre (CNRD)
%A Idrissa Hama
%A Maman Ali Rahamatou
%A Djibrilla Almoustapha Amadou
%A Dodo Boubacar
%A Maliki Abdoulaye Moctar
%A Beidari Ali
%A Harouna Habibou
%A Mbaye Seck
%A Hamidou Laouan
%A Bonkano Ali
%A Akilou Abdouramane
%A Malam Abdou Bad&#233
%A Tour&#233
%A Ibrahim Ali
%J Open Journal of Blood Diseases
%P 50-60
%@ 2164-3199
%D 2025
%I Scientific Research Publishing
%R 10.4236/ojbd.2025.152005
%X <b>Objective</b>: To study the electrical and echocardiographic aspects in patients with major sickle cell syndrome. <b>Methods</b>: This was a prospective descriptive cross-sectional study carried out at the National Reference Center for Sickle Cell Disease and the cardiology department of the National Hospital of Niamey over a period of 6 months (from September 2021 to February 2022). <b>Results</b>: We included 100 patients, including 53 women and 47 men, with a sex ratio of 0.88. The average age was 32.6 &#177; 12 years, with extremes ranging from 16 to 65 years. The SS phenotype represented 87%, the SC phenotype 11% and only 2% of S beta-thalassemia. The mean baseline hemoglobin level was 8.89 &#177; 1.6 g/dL. Electrically, we found QT elongation, left ventricular hypertrophy, sinus tachycardia, negative T waves, first-degree atrioventricular block, right ventricular hypertrophy and left atrial hypertrophy in respectively 28%, 15%, 14%, 11%, 4% and 3% of cases. Echocardiographic abnormalities were dominated by valve involvement in 64% of cases with 53% valve leakage, 4% mitral insufficiency, 5% aortic insufficiency, 2% moderate to severe tricuspid insufficiency; followed by dilation of the left atrium and left ventricle in 30% and 13% of cases respectively. Dilation of the right ventricle and right atrium was present in 3% and 4% of cases, respectively. 4 cases of pulmonary arterial hypertension and 4 cases of ventricular communication were observed. We also noted 1 case of systolic dysfunction, 1 case of hypokinetic dilated cardiomyopathy. The homozygous SS form was found to be the most severe. <b>Conclusion</b>: Sickle cell disease is a severe disease whose prognosis is worsened by cardiac involvement.
%K Electrocardiogram
%K Echocardiography
%K Anomalies
%K Sickle Cell Diseases and CNRD
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=143657