%0 Journal Article
%T <i>In Situ</i> Imaging Studies of Disease Markers and Small Molecules
%A Qincong Feng
%A Yuming Hu
%A Juan Zheng
%J Advances in Molecular Imaging
%P 27-39
%@ 2161-6752
%D 2025
%I Scientific Research Publishing
%R 10.4236/ami.2025.142002
%X Rapid, precise, and sensitive detection of diseases can be realized by <i>in situ</i> imaging of disease markers or small molecules, which can provide prospective disease-related information to patients. This is important for early detection, prognosis, improvement of cure rate, and reduction of mortality. Methods: A DNA-coupled amphiphilic aggregation-induced emission probe (TPE-R-DNA) was synthesized based on nucleic acid exonuclease III-assisted target cycling technology for tumor tissue imaging and prognostic analysis. A dual-targeted DNA tetrahedral nanocarrier (MUC1-Td-AS1411) for breast cancer cell imaging and targeted drug delivery enables real-time imaging of breast cancer and drug therapy. Designed glutathione-gated DNA nanodevices with a highly specific strategy for visualizing miRNA fluorescence Flip-flop for proportional fluorescence imaging of small bioactive molecules in the nucleus. DNA nanoenzymes based catalyzed tyramine deposition reaction for <i>in situ</i> detection of HER2 homodimeric protein status on cell surface, among other methods.
%K Disease Markers
%K <i>In Situ</i> Detection
%K <i>In Situ</i> Imaging
%K Fluorescence Imaging
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=143713