%0 Journal Article
%T Comparative Efficacy and Safety of a Horse Chestnut Formulation vs. Diosmin-Hesperidin in Chronic Venous Insufficiency: Randomized Double-Blind Trial
%A Carlos Romualdo B. Gama
%A Carlos P. Nunes
%A Marcio Steinbruch
%A Mendel Suchmacher
%A Gustavo Falc&#227
%A o Gama
%A Renato Kaufman
%A Spyros Mezitis
%A Aline Levy Sitnoveter
%A Thais Gotfyd Bem Ezri
%A Jo&#227
%A o Paulo L. Daher
%A Mauro Geller
%J International Journal of Clinical Medicine
%P 279-292
%@ 2158-2882
%D 2025
%I Scientific Research Publishing
%R 10.4236/ijcm.2025.166019
%X <b>Background:</b> Chronic venous insufficiency (CVI) is a prevalent and incurable condition that can be managed through both medical and surgical interventions. <b>Objective:</b> To compare the safety and efficacy of a combination of <i>Aesculus</i> <i>hippocastanum</i>, <i>Polygonum</i> <i>acre</i>, <i>Smilax</i> <i>papyracea</i>, and rutin (Group A; <i>n</i><sub>A</sub> = 60) versus a combination of diosmin-hesperidin (Group B; <i>n</i><sub>B</sub> = 60), over a 90-day treatment period, in patients with symptoms consistent with CVI. <b>Methods:</b> Efficacy and safety were assessed using both self-paired and comparative study designs. Study endpoints included: 1) Severity of venous symptoms measured by the Visual Analogue Scale (VAS), 2) Quality of life via the CIVIQ-20 score, 3) Physician&#8217;s assessment score, 4) Patient&#8217;s self-assessment score, and 5) Ease of swallowing the pharmaceutical form, assessed by VAS. Safety profiles were also evaluated. <b>Results:</b> The Group A combination was statistically non-inferior to the Group B combination across all study endpoints, including venous symptom severity, quality of life, and both physician and patient assessments. Group A&#8217;s formulation was reported to perform better on quality-of-life (CIVIQ-20 score-Visit 3) (p &lt; 0.05) and was easier to swallow (p &lt; 0.05). Both treatments were well tolerated. <b>Conclusion:</b> Both regimens were safe and effective, with Group A showing better general performance in relation to Group B.
%K Chronic Venous Insufficiency
%K <i>Aesculus</i> <i>hippocastanum</i> and Associations
%K Diosmin-Hesperidin
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=143525