%0 Journal Article
%T 乳酸化修饰在恶性肿瘤中的革新之路
Lactyltion in Cancers on the Road to Innovation
%A 阴茹月
%A 张磊
%A 梁淑美
%J Advances in Clinical Medicine
%P 1249-1258
%@ 2161-8720
%D 2025
%I Hans Publishing
%R 10.12677/acm.2025.1561847
%X 20世纪20年代，Warburg效应揭示肿瘤细胞即使在有氧条件下仍依赖糖酵解生成ATP，颠覆了乳酸作为缺氧代谢废物的认知。此外，乳酸化修饰的发现进一步拓展了乳酸的生物学功能——其不仅是能量代谢产物，更是通过表观遗传重编程驱动肿瘤恶性进展的关键信号分子。本综述系统解析肿瘤微环境中乳酸代谢与转运的动态网络，阐明组蛋白及非组蛋白乳酸化修饰通过调控代谢–表观–免疫交互轴促进肿瘤增殖、转移及耐药的核心机制，并探讨靶向乳酸化修饰的联合治疗策略，为癌症精准治疗提供新方向。
In the 1920s, the Warburg effect revealed that tumor cells rely on glycolysis to generate ATP even under aerobic conditions, challenging the traditional view of lactate as a hypoxic metabolic waste product. Furthermore, the discovery of lactylation modification has expanded the biological functions of lactate—it is not only an energy metabolite but also a critical signaling molecule that drives malignant tumor progression through epigenetic reprogramming. This review systematically dissects the dynamic network of lactate metabolism and transport within the tumor microenvironment, elucidates the core mechanisms by which histone and non-histone lactylation modifications promote tumor proliferation, metastasis, and drug resistance via regulating the metabolism-epigenetics-immune axis, and explores combination therapeutic strategies targeting lactylation modification, thereby providing novel directions for precision cancer therapy.
%K 乳酸，
%K 乳酸化，
%K 组蛋白乳酸化，
%K 非组蛋白乳酸化，
%K 恶性肿瘤
Lactate
%K Lactylation
%K Histone Lactylation
%K Non-Histone Lactylation
%K Cancers
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=117643