%0 Journal Article
%T Research Progress on Signaling Pathways of LGALS1 in Malignant Tumors
%A Feng Cheng
%A Zizhao Ye
%A Shixin Wei
%A Fuyi Wei
%A Kaiyan Yang
%J Journal of Biosciences and Medicines
%P 142-155
%@ 2327-509X
%D 2025
%I Scientific Research Publishing
%R 10.4236/jbm.2025.136013
%X LGALS1 is a protein belonging to the lectin family, widely distributed across immune and non-immune tissues. Characterized by high evolutionary conservation, LGALS1 specifically binds <i>&#946;</i>-galactosides and functions as a multifunctional bioactive protein. It plays pivotal roles in immune regulation, cell migration, and tumor microenvironment remodeling. In malignant tumors, LGALS1 exhibits complex and context-dependent activities. This review systematically examines the downstream signaling pathways modulated by LGALS1&#8212;including NF-<i>&#954;</i>B, PI3K/AKT/mTOR, MAPK, Hedgehog, TGF-<i>&#946;</i>, and Wnt&#8212;highlighting its dual regulatory roles (promoting or inhibiting tumorigenesis) across cancer types. By synthesizing recent findings, we elucidate the molecular mechanisms underlying LGALS1&#8217;s context-specific effects and its influence on key signaling cascades. These insights aim to provide a theoretical framework and research directions for future studies targeting LGALS1 in cancer therapy.
%K LGALS1
%K Signaling Pathways
%K Malignant Tumors
%K Multifunctional Bioactive Protein
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=143397