%0 Journal Article
%T Clinical Observation Study on the Treatment of Constipation in Female Drug Addicts with Traditional Chinese Medicine Patching
%A Dewei Xu
%A Yun Liu
%A Junhua Zheng
%A Yinuo Zhang
%A Changfeng Huang
%A Xueqin Wang
%A Xuezhi Li
%J Open Access Library Journal
%V 12
%N 7
%P 1-11
%@ 2333-9721
%D 2025
%I Open Access Library
%R 10.4236/oalib.1113722
%X <strong>Objective</strong>: To alleviate the withdrawal symptoms of drug addicts and to explore the clinical efficacy of traditional Chinese medicine dressing on drug-related constipation.<strong> Methods</strong>: A total of 113 patients with constipation after detoxification admitted to a women¡¯s education and correction center in Chongqing were enrolled, and constipation symptoms and quality of life scores, serum gastrointestinal hormones, and intestinal microbiota sequencing indexes were collected in four visits. <strong>Results</strong>: After treatment, the constipation symptom score was significantly decreased (P £¼ 0.01), and the overall effective rate of the traditional and new drug groups was 93.11% and 85.71%, respectively. The serum GAS and 5-HT levels in the traditional drug group were significantly increased (P &lt; 0.05), SP content was significantly decreased (P <span style="text-wrap-mode:wrap;">£¼</span> 0.05), and there was no statistical difference in the VIP content in the traditional drug group and the hormone levels in the new drug group (P £¾ 0.05). The PAC-QOL score of each group was significantly increased (P <span style="text-wrap-mode:wrap;">£¼</span> 0.01), and the incidence and recurrence rate of adverse reactions in the new drug group were higher than those in the traditional drug group (P <span style="text-wrap-mode:wrap;">£¼</span> 0.05). There was no significant difference in the composition and overall abundance of intestinal microbiota (P <span style="text-wrap-mode:wrap;">£¾</span> 0.05). <strong>Conclusion</strong>: Traditional Chinese medicine (TCM) dressing has significant clinical efficacy on drug-related constipation in women and can improve the quality of life of patients, but it has no significant effect on intestinal microbiota in the short term, and further research is needed.<br />
%K Detoxification Personnel
%K Constipation
%K Traditional Chinese Medicine Patching
%K Intestinal Flora
%U http://www.oalib.com/paper/6864625