%0 Journal Article
%T Inhibitory Activity of Methanolic Extracts of Six (06) Medicinal Plants on the Growth of <i>Escherichia coli</i> Resistant to Imipenem by Production of Carbapenemase Isolated at the Tengandogo Hospital in Ouagadougou
%A Macaire Bonkoungou
%A Amana M&#232
%A tuor Dabir&#233
%A Roland N&#226
%A g-Ti&#233
%A ro Meda
%A Abdouramane Soro
%A Reine Adeline Mibiempan Ki
%A Hadidjatou Belem
%A Yasmine Rahimatou Wend-Kuni Tiemtor&#233
%A St&#233
%A phanie Lynseh Carine Sita B&#233
%A nao
%A Jo&#235
%A l G&#233
%A rard Guigma
%A Th&#233
%A ophane Albert Yonli
%A Jacques Simpor&#233
%A Georges Anicet Ou&#233
%A draogo
%J Journal of Biosciences and Medicines
%P 185-196
%@ 2327-509X
%D 2025
%I Scientific Research Publishing
%R 10.4236/jbm.2025.135015
%X The fight against bacterial infections is essentially based on the use of antibiotics. Unfortunately, bacteria have developed resistance mechanisms against antibiotics, particularly those of the <i>&#946;</i>-lactam family. Thus, this study aims to evaluate the inhibitory activity of six medicinal plants resulting from an ethnobotanical investigation of these formidable bacteria. Plant methanol extracts were obtained using Soxhlet. The photometric method was used to measure the absorbances of bacterial (<i>Escherichia </i><i>c</i><i>oli</i>) suspensions and for the phytochemical assay of plant extracts. <i>Terminalia </i><i>laxiflora</i> (<i>T. </i><i>laxiflora</i>) Engl. & Diels proves to be the most effective plant with an optical density (OD) of 0.322 against 1.133 of the positive control and 0.901 of the antibiotic. The total phenolic content of the methanolic extract of <i>T. </i><i>laxiflora</i> Engl. & Diels was 68.45 &#177; 0.11 mg EAG/100 mg extract. The total flavonoids were 2.71 &#177; 0.09 mg EQ/100mg of extract. The antioxidant content of the extract (820.46 &#177; 0.17 &#181;mol EAA/g of extract) is higher than the contents of quercetin (646.85 &#181;mol EAA/g of extract) and trolox (765.99 &#181;mol EAA/g of extract). As for the FRAP method, the extract gave a content (4190.93 &#177; 1.79 &#181;mol EAA/g of extract) which exceeds that of quercetin (5991.29 &#177; 1.33 &#181;mol EAA/g of extract). At the level of the ABTS method, the extract still gave a value (11935.45 &#177;3.18 &#181;mol EAA/g of extract) higher than trolox (8137.61 &#177; 4.04 &#181;mol EAA/g of extract).
%K Medicinal Plants
%K <i>Escherichia coli</i>
%K Carbapenemase
%K Tengandogo Hospital
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=142682