%0 Journal Article
%T 铜和铜死亡在泌尿系统肿瘤中的研究进展<br>Research Progress on Copper and Cuproptosis in Urological Tumors
%A 张东升
%A 于圣杰
%J Advances in Clinical Medicine
%P 52-60
%@ 2161-8720
%D 2025
%I Hans Publishing
%R 10.12677/acm.2025.1551341
%X 铜死亡是一种新发现的细胞死亡形式&#65292;由细胞内铜离子(Cu<sup>2</sup><sup>+</sup>)异常蓄积触发。该机制在肿瘤研究领域引发广泛关注&#65292;因其展现了作为癌症治疗新靶点的巨大潜力。在泌尿系统肿瘤中&#65292;前列腺癌(PC)、膀胱癌(BC)和肾癌(RCC)是常见的恶性肿瘤&#65292;临床治疗面临严峻挑战。最新研究表明&#65292;铜稳态失衡与泌尿系统肿瘤恶性进展密切相关&#65292;铜死亡机制的探讨为理解肿瘤细胞的生存与死亡提供了新的方向。本文就铜死亡在泌尿系统肿瘤中的最新研究进展作一综述&#65292;包括铜与铜代谢的相互关系、铜死亡机制的阐述、铜在治疗中的应用以及未来的研究前景&#65292;以期为泌尿系统肿瘤治疗提供新的视角。<br>Cuproptosis, a newly discovered regulated cell death mechanism, is induced by excessive intracellular copper accumulation. This mechanism has garnered significant attention in cancer research due to its potential as a novel therapeutic target. Among urological tumors, prostate cancer (PC), bladder cancer (BC), and renal cell carcinoma (RCC) are common malignancies that pose formidable challenges in clinical management. Emerging evidence highlights the critical role of copper homeostasis imbalance in the malignant progression of urological tumors, and the exploration of cuproptosis mechanisms provides novel insights into the survival and death of tumor cells. This review summarizes recent advances in cuproptosis research within urological tumors, including the interrelationship between copper and copper metabolism, elucidation of cuproptosis mechanisms, therapeutic applications of copper, and future research prospects. The aim is to offer new perspectives for advancing treatment strategies for urological tumors.
%K 铜&#65292
%K 铜死亡&#65292
%K 泌尿系统肿瘤&#65292
%K 研究进展<br>Copper
%K Cuproptosis
%K Urological Tumors
%K Research Progress
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=113647