%0 Journal Article
%T Severe Hypertension with Hypokalemia and Nephroangiosclerosis Due to Liddle Syndrome&#8217;s Mutation<br>&#8212;Liddle Syndrome Nephroangiosclerosis
%A Kamel El-Reshaid
%A Shaikha Al-Bader
%J Open Journal of Nephrology
%P 152-159
%@ 2164-2869
%D 2025
%I Scientific Research Publishing
%R 10.4236/ojneph.2025.152014
%X <b>Background:</b> Liddle syndrome (LS) is a rare autosomal-dominant cause of early-life hypertension. It is associated with hypokalemic metabolic alkalosis, hyporeninemia, and suppressed aldosterone secretion. Its morbidity and mortality are associated with hypertension and hypokalemia. <b>The</b> <b>Case</b><b>:</b> An 18-year-old man with severe hypertension, hypokalemia and renal failure for years. He was treated with multiple antihypertensive drugs yet without adequate control. In this patient; LS was confirmed by biochemical and hormonal profiles as well as genetic testing. His close family-members were clinically normal and by genetic testing indicating a new mutation in our patient. He was subjected to kidney biopsy since he had; high serum creatinine at 140 umol/L and bilateral small kidneys at 9 cm, in longitudinal diameter, with thin and echogenic cortex. It showed moderate nephroangiosclerosis. Initially, he was treated with low-salt diet, Amiloride 20 mg daily, slow K and antihypertensives (Amlodipine 10 mg daily and alpha methyl dopa 250 mg twice daily). Subsequently, antihypertensives were reduced to only Amlodipine 5 mg daily. He remained stabilized her disease up to 2 years of follow-up. <b>Conclusion:</b> LS should be considered in hypertensive children with hypokalemia since it requires special management to avoid its hypokalemic and cardiovascular complications as well as nephroangiosclerosis.
%K Amiloride
%K Genetic Testing
%K Hypertension
%K Hypokalemia
%K Liddle Syndrome
%K Nephroangiosclerosis
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=142328