%0 Journal Article
%T 铜绿假单胞菌RSCVs的致病机制与临床干预研究进展<br>Rugose Small Colony Variants (RSCVs) in <i>Pseudomonas aeruginosa</i>: Pathogenesis, Clinical Implications, and Therapeutic Advancements
%A 俞清
%A 杜小幸
%J Advances in Clinical Medicine
%P 2715-2722
%@ 2161-8720
%D 2025
%I Hans Publishing
%R 10.12677/acm.2025.1541232
%X 铜绿假单胞菌(<i>Pseudomonas</i> <i>aeruginosa</i>)的皱缩型小菌落变异体(Rugose Small Colony Variants, RSCVs)是一种具有高生物被膜形成能力和高适应性的表型变异体&#65292;常在囊性纤维化患者的慢性感染分离株中被发现。其形成机制主要与环二鸟苷酸(c-di-GMP)信号通路的异常激活密切相关。本文系统地总结了RSCVs的分子机制、临床意义以及新型治疗策略&#65292;以期为RSCVs的基础研究与临床干预提供系统性参考。<br>Rugose Small Colony Variants (RSCVs) of <i>Pseudomonas aeruginosa</i> are phenotypic variants with high biofilm-forming capacity and adaptability, frequently identified in chronic infection isolates from patients with cystic fibrosis. Their formation is primarily associated with the abnormal activation of the cyclic diguanylate monophosphate (c-di-GMP) signaling pathway. This review systematically summarizes the molecular mechanisms, clinical significance, and novel therapeutic strategies of RSCVs, aiming to provide a comprehensive reference for the basic research and clinical intervention of RSCVs.
%K 铜绿假单胞菌&#65292
%K RSCVs&#65292
%K 生物被膜&#65292
%K c-di-GMP&#65292
%K 抗生素耐药<br><i>Pseudomonas aeruginosa</i>
%K RSCVs
%K Biofilm
%K c-di-GMP
%K Antibiotic Resistance
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=112567