%0 Journal Article
%T 肠道菌群对肝硬化相关并发症的发病机制及治疗策略的影响研究
Study on the Influence of Intestinal Flora on the Pathogenesis and Treatment Strategy of Related Complications of Liver Cirrhosis
%A 王莎
%A 杨婧
%A 董程萱
%A 马红琳
%A 胡绍山
%J Advances in Clinical Medicine
%P 2009-2015
%@ 2161-8720
%D 2025
%I Hans Publishing
%R 10.12677/acm.2025.1541148
%X 肝硬化是一种由各种病因引起的慢性、进行性、弥漫性终末期肝脏病变，常伴随多种并发症的发生，例如腹水、肝性脑病、食管胃底静脉曲张、自发性腹膜炎等。这些并发症不仅影响患者的生活质量，还显著增加了死亡风险。近年来，随着对消化系统疾病的深入认识，越来越多的研究表明，肠道菌群在肝硬化的发生发展及其相关并发症的发生中起着关键作用。然而，目前关于肠道菌群如何影响肝硬化及其并发症的具体机制仍不完全清晰，且临床治疗策略尚未得到有效落实。本综述旨在深入探讨肠道菌群在肝硬化相关并发症中的发病机制，包括其通过免疫调节、代谢产物及肝肠轴等多种途径的影响。同时，我们还将回顾当前的治疗策略，为未来的研究和治疗方法提供参考和启示。
Cirrhosis is a chronic, progressive and diffuse end-stage liver disease caused by various causes, often accompanied by a variety of complications, such as ascites, hepatic encephalopathy, esophageal and gastric varices, spontaneous peritonitis and so on. These complications not only affect the quality of life of patients, but also significantly increase the risk of death. In recent years, with the in-depth understanding of digestive system diseases, more and more studies show that intestinal flora plays a key role in the occurrence and development of liver cirrhosis and related complications. However, the specific mechanism of how intestinal flora affects cirrhosis and its complications is still not completely clear, and the clinical treatment strategy has not been effectively implemented. This review aims to explore the pathogenesis of intestinal flora in related complications of liver cirrhosis, including its influence through immunomodulation, metabolites and hepatointestinal axis. At the same time, we will also review the current treatment strategies to provide reference and enlightenment for future research and treatment methods.
%K 肝硬化，
%K 肠道菌群，
%K 并发症，
%K 发病机制，
%K 治疗策略
Cirrhosis
%K Intestinal Flora
%K Complication
%K Nosogenesis
%K Therapeutic Strategy
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=111966