%0 Journal Article
%T 针药结合治疗少弱精子症有效性的Meta分析
Meta-Analysis on the Effectiveness of Combined Acupuncture and Medication Treatment for Oligoasthenozoospermia
%A 齐上毅
%A 孙一鸣
%J Journal of Clinical Personalized Medicine
%P 1205-1214
%@ 2334-3443
%D 2025
%I Hans Publishing
%R 10.12677/jcpm.2025.42295
%X 目的：评价针药结合治疗少弱精子症有效性及安全性。方法：计算机检索中国生物医学文献数据库(CBM)、中国期刊全文数据库(CNKI)、维普期刊数据库、万方资源数据库、Pubmed、Cochrane图书馆中关于针刺结合药物治疗少弱精子症的随机对照试验，并手工检索相关杂志，由两位研究者独立进行筛选和资料提取后，依据Cochrane Handbook 5.1.0偏倚风险评估工具评价纳入研究质量，应用Revman 5.4软件进行Meta分析。结果：纳入5篇文献，共485例患者，其中试验组233例，对照组252例。Meta分析结果显示，与对照组相比，针药结合对少弱精子治疗率显著提升(RR = 1.22, 95% CI [1.12, 1.33])；提高精子活动水平(A + B)级(MD = 9.03, 95% CI [7.79, 10.26])；提高精子密度(MD = 10.51, 95% CI [8.71, 12.31])和提高睾酮水平(MD = 0.6, 95% CI [0.45, 0.75])。结论：与单一治疗相比，针刺与药物联用能明显提高精子的活动率，精子密度和睾酮，由于纳入的文献其研究方法学质量不高，有待进一步进行高质量的研究对其疗效及安全性进行研究。
Objective: To evaluate the efficacy and safety of acupuncture combined with medication in the treatment of oligoasthenozoospermia. Methods: Computerized searches were conducted in the Chinese Biomedical Literature Database (CBM), Chinese Journal Full-text Database (CNKI), VIP Journal Database, Wanfang Resources Database, PubMed, and Cochrane Library for randomized controlled trials on acupuncture combined with medication for oligoasthenozoospermia. Hand searches were also conducted in relevant journals. Two researchers independently screened and extracted data. The quality of the included studies was evaluated using the Cochrane Handbook 5.1.0 Risk of Bias Assessment Tool. Meta-analysis was performed using Revman 5.4 software. Results: Five articles were included, involving 485 patients. Among them, 233 patients were in the acupuncture group and 252 patients were in the control group. The meta-analysis results showed that compared with the control group, acupuncture combined with medication significantly increased the treatment rate of oligoasthenozoospermia (RR = 1.22, 95% CI [1.12, 1.33]); increased the grade of sperm motility (A + B) (MD = 9.03, 95% CI [7.79, 10.26]); increased sperm density (MD = 10.51, 95% CI [8.71, 12.31]) and increased testosterone levels (MD = 0.6, 95% CI [0.45, 0.75]). Conclusion: Compared with single treatment, the combination of acupuncture and medication can significantly improve sperm motility, sperm density and testosterone levels. Due to the low methodological quality of the included studies, further high-quality research is needed to investigate its efficacy and safety.
%K 少弱精子症，
%K 针刺，
%K Meta分析
Oligoasthenozoospermia
%K Acupuncture
%K Meta-Analysis
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=111861