%0 Journal Article
%T 视黄酸在哮喘气道炎症中的研究进展<br>Advances in the Research of Retinoic Acid in Asthmatic Airway Inflammation
%A 欧阳涟兮
%A 符州
%A 牛超
%J Journal of Clinical Personalized Medicine
%P 1179-1185
%@ 2334-3443
%D 2025
%I Hans Publishing
%R 10.12677/jcpm.2025.42292
%X 哮喘是一种慢性气道炎症性疾病&#65292;其特征为可逆性的气流受限和呼吸道高反应性。当前哮喘治疗仍以吸入性糖皮质激素(ICS)和长效<i>&#946;</i>2受体激动剂(LABA)联合疗法为主&#65292;开发低毒性的辅助治疗策略对于临床哮喘防治至关重要。视黄酸(Retinoic acid, RA)是维生素A的主要生物活性代谢产物&#65292;通过促进T细胞增殖和延长其存活时间等&#65292;在哮喘中起核心作用。在此&#65292;本文就RA与支气管哮喘关系的研究进展进行综述。<br>Asthma is a chronic airway inflammatory disease characterized by reversible airflow limitation and airway hyperresponsiveness. Current therapeutic regimens primarily rely on combined therapy with inhaled corticosteroids (ICS) and long-acting <i>&#946;</i>2-agonists (LABAs). The development of low-toxicity adjuvant therapeutic strategies is therefore critical for clinical asthma management. Retinoic acid (RA), the primary biologically active metabolite of vitamin A, plays a central role in asthma by promoting T cell proliferation, prolonging T cell survival, and modulating immune responses. This review summarizes recent advances in understanding the relationship between RA and bronchial asthma.
%K 视黄酸&#65292
%K 儿童&#65292
%K 哮喘&#65292
%K 气道炎症<br>Retinoic Acid
%K Children
%K Asthma
%K Airway Inflammation
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=111858