%0 Journal Article
%T Evaluation of Hypoglycemic Effects of a Variety of Chinese Herbal Medicines Based on Silkworm (<i>Bombyx mori</i>) Model
%A Cheng Tan
%A Huani Chen
%A Rong Li
%A Jiaming Hou
%A Nan Chen
%A Li Qian
%J Journal of Biosciences and Medicines
%P 115-127
%@ 2327-509X
%D 2025
%I Scientific Research Publishing
%R 10.4236/jbm.2025.134011
%X <b>Objectiv</b><b>e:</b> To establish a low-cost way to evaluate the efficacy of hypoglycemic herbs. <b>Methods: </b>The silkworms were divided into control group, model group, metformin group, and various herbal extracts group, and were reared at 16&#730;C - 20&#730;C until the sixth day of modeling, and blood glucose was detected in all silkworms on the sixth day. <b>Results:</b> High-jasmine crude polysaccharide (H-JCP), total flavonoids of <i>P</i><i>aederia</i><i> scandens</i> (TFPS), total flavonoids of hibiscus flowers (TFHF), low-total flavonoids of chamomile (L-TFC), high-total flavonoids of chamomile (H-TFC), low-total flavonoids of potentilla discolor (L-TFPD), high-total flavonoids of potentilla discolor (H-TFPD), low-golden flowers tea extract (L-GFTE), high-golden flowers tea extract (H-GFTE), low-guava extract (L-GE) and high-guava extract(H-GE) had different hypoglycemic effects in the silkworm, respectively, H-JCP, TFPS, TFHF, H-TFC had a certain inhibitory effect on <i>&#945;</i>-glucosidase activity, while crude polysaccharide of <i>Polyporus </i><i>umbellatus</i> (CPPU), buckwheat shell total flavonoids (BSTF), low-hawthorn leaves flavonoids (L-HLF) and high-hawthorn leaves flavonoids (H-HLF) were not as effective in lowering the hypoglycemic effect. <b>Conclusion:</b> A model of diabetes in the silkworm, established at low temperatures, allowed a preliminary evaluation of the hypoglycemic effect of the herbal extracts.
%K Silkworm
%K Diabetes
%K Chinese Herbs
%K <i>&#945
%K </i>-Glycosidase
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=141925