%0 Journal Article
%T 腹腔穿刺引流治疗急性重症胰腺炎的研究进展<br>Research Progress in the Treatment of Severe Acute Pancreatitis by Peritoneal Puncture Drainage
%A 李敬毅
%A 张健
%J Journal of Clinical Personalized Medicine
%P 936-944
%@ 2334-3443
%D 2025
%I Hans Publishing
%R 10.12677/jcpm.2025.42262
%X 本综述系统探讨了腹腔穿刺引流(Abdominal Paracentesis Drainage, APD)在重症急性胰腺炎(Severe Acute Pancreatitis, SAP)治疗中的临床应用价值及其疗效。SAP作为一种危重急症&#65292;具有较高的致死率和多种并发症风险。APD作为一种微创治疗技术&#65292;其主要作用机制是通过清除胰腺炎相关性腹腔积液(Pancreatitis Associated Abdominal Fluid, PAAF)中的炎性因子和胰酶等有害物质&#65292;从而有效缓解全身炎症反应综合征(Systemic Inflammatory Response Syndrome, SIRS)的临床症状。这一治疗方法的创新性在于其能够直接针对SAP病理生理过程中的关键环节进行干预&#65292;为改善患者预后提供了新的治疗思路。本文系统回顾了现有关于APD在SAP治疗中的研究&#65292;分析了APD的作用机制、临床实施时机、疗效及安全性。通过汇总大量临床研究数据&#65292;我们发现APD能够显著改善SAP患者的临床结局&#65292;降低并发症发生率&#65292;并减少住院时间和医疗费用。然而&#65292;APD的具体应用标准和操作规范尚未达成一致&#65292;不同研究在最佳实施时机和长期疗效方面存在一定差异。综上所述&#65292;APD在SAP治疗中展示出良好的临床前景&#65292;但仍需进一步的大规模随机对照试验来验证其效果和安全性。未来的研究应重点关注APD的优化实施策略&#65292;以期为SAP患者提供更加有效和安全的治疗方案。<br>This review systematically investigates the clinical value and efficacy of Abdominal Paracentesis Drainage (APD) in the treatment of Severe Acute Pancreatitis (SAP), a critical emergency with high lethality and multiple complication risks. As a minimally invasive therapeutic technique, the main mechanism of APD is to remove the inflammatory factors and pancreatic enzymes and other harmful substances in Pancreatitis Associated Abdominal Fluid (PAAF), thus effectively relieving Systemic Inflammatory Response Syndrome (SIRS). The innovation of this treatment is that it can directly target the key links in the pathophysiological process of SAP, which provides a new therapeutic idea to improve the prognosis of patients. We systematically reviewed studies on APD for treating SAP, analyzing its mechanism of action, clinical implementation timing, efficacy, and safety. By pooling data from numerous clinical studies, we found that APD significantly improves clinical outcomes, reduces complication rates, and decreases hospitalization length and medical costs for SAP patients. However, there is no consensus on specific criteria for APD, and studies differ on its optimal timing and long-term efficacy. In summary, APD shows promise in treating SAP, but further large-scale randomized controlled trials are needed to verify its efficacy and safety. Future studies should focus on optimizing APD implementation strategies to provide more effective and safe treatment options for SAP patients.
%K 重症急性胰腺炎&#65292
%K 微创治疗&#65292
%K 穿刺时机<br>Severe Acute Pancreatitis
%K Minimally Invasive Treatment
%K Puncture Timing
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=111390