%0 Journal Article
%T m<sup>6</sup>A甲基转移酶ZC3H13在肿瘤中的作用及研究进展<br>The Role of m<sup>6</sup>A Methyltransferase ZC3H13 in Tumors and Its Research Progress
%A 董亚玲
%A 朱志博
%A 苏夏艺
%A 白洁
%A 魏秀珍
%A 张百红
%J Journal of Clinical Personalized Medicine
%P 767-774
%@ 2334-3443
%D 2025
%I Hans Publishing
%R 10.12677/jcpm.2025.42241
%X 随着精准医疗和个性化治疗的发展&#65292;肿瘤研究领域不断探索新的分子靶点和治疗策略。含锌指CCCH型13 (Zinc finger CCCH-type containing 13, ZC3H13)作为一种重要的N<sup>6</sup>-甲基腺苷(N<sup>6</sup>-methyladenosine, m<sup>6</sup>A)甲基转移酶&#65292;近年来受到广泛关注&#65292;其在肿瘤发生、发展及转移过程中的作用逐渐被揭示。本文综述ZC3H13在肿瘤中的作用机制及其研究进展。本文的研究重点在于揭示ZC3H13如何通过调控甲基化影响RNA代谢及特定信号通路影响肿瘤细胞的增殖、凋亡和侵袭能力&#65292;以及其在肿瘤微环境中的作用。此外&#65292;本文还探讨了ZC3H13作为潜在生物标志物和治疗靶点的可能性。以期为理解肿瘤的分子机制、开发新型抗肿瘤药物以及提高肿瘤治疗效果提供新的策略。<br>With the development of precision medicine and personalized therapy, the field of cancer research continues to explore new molecular targets and treatment strategies. Zinc finger CCCH-type containing 13 (ZC3H13), as an important N<sup>6</sup>-methyladenosine (m<sup>6</sup>A) methyltransferase, has attracted extensive attention in recent years, and its role in tumorigenesis, development and metastasis has been gradually revealed. This article reviews the mechanism of action of ZC3H13 in tumors and its research progress. This study focuses on revealing how ZC3H13 affects RNA metabolism and specific signaling pathways by regulating methylation, as well as its role in the tumor microenvironment. In addition, the potential of ZC3H13 as a potential biomarker and therapeutic target is also explored, in order to provide new strategies for understanding the molecular mechanism of tumors, developing new anti-tumor drugs, and improving the therapeutic effect of tumors.
%K 甲基转移酶&#65292
%K ZC3H13&#65292
%K 肿瘤&#65292
%K 信号通路&#65292
%K 免疫微环境<br>Methyltransferase
%K ZC3H13
%K Tumor
%K Signaling Pathways
%K Immune Microenvironment
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=111242