%0 Journal Article
%T 血清vWF、LTF与Hct联合检测对急性胰腺炎严重程度的预测价值
The Predictive Value of Combined Detection of Serum vWF, LTF, and Hct for the Severity of Acute Pancreatitis
%A 史航瑞
%A 孙远松
%A 李贺
%J Journal of Clinical Personalized Medicine
%P 665-673
%@ 2334-3443
%D 2025
%I Hans Publishing
%R 10.12677/jcpm.2025.42229
%X 目的：探讨血管性血友病因子(vWF)、乳转铁蛋白(LTF)及红细胞比容(Hct)对急性胰腺炎(AP)病情严重程度的预测价值。方法：回顾性纳入2021年6月至2022年12月安徽医科大学第二附属医院急诊外科收治的260例AP患者，依据《2012亚特兰大分类标准》分为SAP组(重症组)与非SAP组。收集患者基线资料、实验室指标(包括ELISA法检测的血清vWF、LTF水平)及入院24小时内CTSI评分、48小时内SOFA评分。通过二元Logistic回归分析筛选SAP独立危险因素并构建联合预测模型，采用ROC曲线评估其诊断效能并与SOFA、CTSI评分对比。结果：SAP组与非SAP组在年龄、心率、白细胞计数、淋巴细胞百分比及Hct等指标差异显著。Spearman相关分析显示，Hct与AP严重程度正相关(r = 0.581)，vWF (r= −0.566)、LTF (r = −0.462)呈负相关。Logistic回归证实三者均为SAP独立危险因素(均p < 0.05)。联合预测模型AUC为0.925，显著优于SOFA (0.907)及CTSI (0.776)，灵敏度85.4%、特异度86.0%。结论：vWF、LTF、Hct联合模型对SAP具有高灵敏度和特异度，可作为早期识别高危患者的有效工具，其预测效能优于传统评分系统。
Objective: To explore the predictive value of von Willebrand factor (vWF), lactotransferrin (LTF) and hematocrit (Hct) for the severity of acute pancreatitis (AP). Methods: A total of 260 AP patients admitted to the Department of Emergency Surgery of the Second Affiliated Hospital of Anhui Medical University from June 2021 to December 2022 were retrospectively enrolled and divided into SAP and non-SAP groups according to the 2012 Atlanta Classification. Baseline data, laboratory indexes (including serum vWF and LTF levels detected by ELISA) and CTSI scores within 24 hours of admission and SOFA scores within 48 hours were collected. Binary Logistic regression identified SAP risk factors and a combined prediction model. Diagnostic efficacy was evaluated by ROC curve and compared with SOFA and CTSI scores. Results: Significant differences were found between SAP group and non-SAP group in age, heart rate, white blood cell count, lymphocyte percentage and Hct. Spearman correlation analysis showed that Hct was positively correlated with the severity of AP (r = 0.581), while vWF (r = −0.566) and LTF (r = −0.462) were negatively correlated. Logistic regression confirmed that all three were independent risk factors for SAP (all p < 0.05). The AUC of the combined prediction model was 0.925, which was significantly better than SOFA (0.907) and CTSI (0.776), with sensitivity of 85.4% and specificity of 86.0%. Conclusion: The combined model of vWF, LTF and Hct has high sensitivity and specificity for SAP and can be used as an effective tool for early identification of high-risk patients, with better predictive efficacy than traditional scoring systems.
%K 血管性血友病因子，
%K 乳转铁蛋白，
%K 红细胞比容，
%K 急性胰腺炎，
%K 预测
Von Willebrand Factor
%K Lactoferrin
%K Hematocrit
%K Acute Pancreatitis
%K Prediction
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=111105