%0 Journal Article
%T The Effects of BCAA-Enriched Essential Amino Acid Mixtures and Exercise on the Muscles: A Randomized, Single-Blind, Placebo-Controlled Trial
%A Yuki Hirashima
%A Kazuma Ariga
%A Yuri Urakawa
%A Sakura Mashiki
%A Takatoshi Ogami
%A Tomoyasu Kamiya
%A Kinya Takagaki
%A Naoya Sekiguchi
%A Toshio Moritani
%J Food and Nutrition Sciences
%P 357-373
%@ 2157-9458
%D 2025
%I Scientific Research Publishing
%R 10.4236/fns.2025.164020
%X <b>Background: </b>Protein intake provides the essential amino acids (EAA) necessary for promoting muscle protein synthesis. Branched-chain amino acids (BCAA) belonging to the EAA in particular are known to have more potent effects. We developed BCAA-enriched essential amino acids (BEAA<sup>&#174;</sup>) to improve muscle health and performance. Therefore, we aimed at comparing the effects of BEAA<sup>&#174;</sup> and whey protein intake in combination with exercise on muscle mass and strength in humans. <b>Methods: </b>A randomized, single-blind, placebo-controlled, parallel-group study was conducted to evaluate the impact of BEAA<sup>&#174;</sup> and exercise on the muscles in healthy participants. Seventy-five healthy male participants were enrolled and randomly divided into three groups; the BCAA-enriched essential amino acids (BEAA), whey protein (WHEY), and placebo (PLA) groups. The participants consumed either the food containing BEAA<sup>&#174;</sup> 3 g, whey protein 20 g, or dextrin 3 g for 12 weeks. The participants exercised five times weekly, and the exercise load was gradually increased. The primary (muscle mass) and secondary (muscle strength) outcomes were evaluated. <b>Results: </b>Whole-body muscle mass and lower-limb muscle mass showed statistical significance in the BEAA group compared to the PLA group (P &lt; 0.05), whereas there was no difference between the WHEY group and the PLA group. Regarding the knee joint extensor muscle strength, no significant differences were observed between the BEAA group and the WHEY group when compared to the PLA group. No adverse events attributable to the test foods were observed during the study period. <b>Conclusions: </b>Overall, BEAA<sup>&#174;</sup> was shown to increase muscle mass in healthy adult males when combined with exercise.
%K Essential Amino Acid
%K Branched-Chain Amino Acid
%K BEAA
%K Whey Protein
%K Muscle Mass
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=141852