%0 Journal Article %T Massive Splenic Infarction Following COVID-19 Infection, with Histopathological Observations, and Review of the Literature %A Yousef Samir Amr %A Aseel Qassem Al-Omari %A Mousa Husein Saadeh %A Samir Sami Amr %J Open Journal of Pathology %P 69-89 %@ 2164-6783 %D 2025 %I Scientific Research Publishing %R 10.4236/ojpathology.2025.152007 %X We report a 63-year-old man who developed massive splenic infarction two months following COVID-19 infection. He presented with high grade fever, weakness, dysuria and chronic productive cough. He was found to have a large splenic infarction involving most of the spleen. We document the course and outcome of his illness, and the histopathological findings of the resected spleen. A discussion of COVID-19 associated hypercoagulability is presented, with a comprehensive review of the literature on splenic infarction associated with COVID-19 infection. %K COVID-19 %K Splenic Infarction %K Hyper-Coagulability %K Thrombosis %U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=141746