%0 Journal Article
%T IDO及HLA-G在妊娠期糖尿病中的表达及临床意义<br>Expression and Clinical Significance of IDO and HLA-G in Gestational Diabetes Mellitus
%A 张翠萍
%A 戴勤慧
%A 方笑白
%A 郭永
%J Advances in Clinical Medicine
%P 306-310
%@ 2161-8720
%D 2025
%I Hans Publishing
%R 10.12677/acm.2025.154934
%X 妊娠期糖尿病(GDM)是妊娠期间常见的糖代谢异常疾病。本文探讨了吲哚胺2,3-双加氧酶(IDO)与人类白细胞抗原-G (HLA-G)两种免疫调节分子在GDM中的表达及临床意义。本文指明IDO在妊娠期间的活性增加有助于保护胎儿免受母体免疫系统的攻击&#65292;但在GDM条件下会造成IDO活性降低。HLA-G通过抑制免疫细胞功能维持母胎间免疫平衡&#65292;但GDM会导致血清中可溶性HLA-G水平下降甚至变异。IDO活性降低和HLA-G表达变化提示免疫耐受受损&#65292;联合检测这两种分子可为GDM的早期诊断、病情监控及治疗评估提供重要信息。<br>Gestational Diabetes Mellitus (GDM) is a common disorder of glucose metabolism during pregnancy. This article explores the expression and clinical significance of two immunomodulatory molecules, Indoleamine 2,3-Dioxygenase (IDO) and Human Leukocyte Antigen-G (HLA-G), in GDM. It is indicated that the increased activity of IDO during pregnancy helps protect the fetus from maternal immune system attacks, but under GDM conditions, it leads to a reduction in IDO activity. HLA-G maintains immune balance between mother and fetus by inhibiting immune cell function, but GDM causes a decrease or even variation in the levels of soluble HLA-G in the serum. The reduction in IDO activity and changes in HLA-G expression suggest impaired immune tolerance. The combined detection of these two molecules can provide crucial information for the early diagnosis, monitoring, and treatment evaluation of GDM.
%K GDM&#65292
%K IDO&#65292
%K HLA-G&#65292
%K 联合表达<br>GDM
%K IDO
%K HLA-G
%K Joint Expression
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=110682