%0 Journal Article
%T 马勃孢子粉治疗糖尿病足溃疡的疗效及安全性研究
Study on the Efficacy and Safety of Puffball Spore Powder in the Treatment of Diabetes Foot Ulcer
%A 肖寒露
%A 何超芹
%A 沈丹萍
%J Advances in Clinical Medicine
%P 2569-2577
%@ 2161-8720
%D 2025
%I Hans Publishing
%R 10.12677/acm.2025.153894
%X 目的：探索马勃孢子粉治疗糖尿病足溃疡的效果及安全性。方法：按照纳排标准纳入81例糖尿病足溃疡患者，对照组(41例)行常规治疗，研究组(40例)行常规治疗 + 马勃孢子粉治疗。收集两组患者基本资料，比较两组的临床疗效、创面面积、细菌培养阳性率炎症指标及创面渗出液指标，并进行安全性评价。结果：治疗后，与对照组相比，研究组治疗总有效率显著提高；创面面积显著缩小；细菌培养阳性率显著降低；炎症指标(CRP、ESR、IL-6和TNF-α)水平显著降低；创面渗出液指标TIMP-1和VEGF水平均明显升高，而MMP9水平明显降低。结论：马勃孢子粉治疗糖尿病足溃疡疗效显著，安全性好，值得临床推广使用。
Objective: To explore the efficacy and safety of puffball spore powder in the treatment of diabetes foot ulcers. Methods: According to the inclusion and exclusion criteria, 81 patients with diabetes foot ulcers were included. The control group (41 cases) received basic treatment, and the research group (40 cases) received basic treatment + puffball spore powder treatment. The basic data of the two groups were collected, and the clinical efficacy, wound area, positive rate of bacterial culture, inflammatory index, and wound exudate index of the two groups were compared, and the safety was evaluated. Results: After treatment, compared with the control group, the total effective rate of the study group was significantly improved; the area of the wound decreased significantly; the positive rate of bacterial culture obviously decreased; the levels of inflammatory markers (CRP, ESR, IL-6, and TNF-α) were markedly reduced; the levels of TIMP-1 and VEGF in wound exudate were significantly up-regulated, while the level of MMP9 was significantly down-regulated. Conclusion: The efficacy and safety of puffball spore powder in the treatment of diabetes foot ulcers are significant, and it is worthy of clinical application.
%K 马勃孢子粉，
%K 糖尿病足溃疡，
%K 临床疗效，
%K 炎症指标，
%K 安全性
Puffball Spore Powder
%K Diabetes Foot Ulcer
%K Clinical Efficacy
%K Inflammatory Marker
%K Security
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=110466