%0 Journal Article
%T Primary Male Neuroendocrine Breast Carcinoma: A Case Report and Review of Literature
%A Ilyas Benbenaissa
%A Ayoub Ezzidi
%A Bouchra Fakhir
%A Hamid Asmouki
%A Abderraouf Soummani
%J Yangtze Medicine
%P 86-95
%@ ****-****
%D 2025
%I Scientific Research Publishing
%R 10.4236/ym.2025.91008
%X Primary neuroendocrine carcinoma of the male breast is an exceptionally rare entity, with fewer than 50 cases documented in the literature. We present a case of a 71-year-old male with a rapidly growing retro-areolar mass. The histopathological and immunohistochemical evaluation confirmed a diagnosis of primary neuroendocrine carcinoma of the breast, with positivity for chromogranin A, synaptophysin, and CD56 and a Ki-67 proliferative index of 30%. The patient underwent total mastectomy with axillary lymph node dissection followed by adjuvant tamoxifen. At 24-month follow-up, he remains disease-free. This case highlights the diagnostic challenges of male neuroendocrine breast carcinoma (NEBC) and emphasizes the critical role of histopathology and immunohistochemistry in achieving an accurate diagnosis. We provide a comprehensive review of the literature, propose a management algorithm, and suggest future research directions to address knowledge gaps in this rare malignancy. This report adheres to the SCARE 2020 criteria for surgical case reports.
%K Male Breast Cancer
%K Neuroendocrine Carcinoma
%K Chromogranin A
%K Synaptophysin
%K Immunohistochemistry
%K Tamoxifen
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=141665