%0 Journal Article
%T 内质网应激在心血管疾病中的研究进展<br>Research Advances in Endoplasmic Reticulum Stress in Cardiovascular Disease
%A 陈雨晴
%A 刘莎莎
%J Advances in Clinical Medicine
%P 2505-2512
%@ 2161-8720
%D 2025
%I Hans Publishing
%R 10.12677/acm.2025.153886
%X 本文讨论了内质网应激在心脏和血管疾病中的角色&#65292;特别是聚焦于三个主要途径&#65306;PERK、IRE1和ATF6&#65292;以及它们如何影响心脏的健康状况。研究显示&#65292;内质网应激通过这些路径可以调控心肌细胞的生存、血管内皮的工作方式以及血管平滑肌细胞的行为&#65292;这些都对心血管系统的健康至关重要。一定程度的内质网应激可以帮助细胞适应不利条件&#65292;但如果应激过度&#65292;可能会损害心血管功能&#65292;加重疾病的发展。<br>This article discusses the role of endoplasmic reticulum stress in heart and vascular disease, focusing specifically on three major pathways: PERK, IRE1, and ATF6, and how they affect the health of the heart. The study shows that endoplasmic reticulum stress, through these pathways, can regulate the survival of cardiomyocytes, the way the vascular endothelium works, and the behavior of vascular smooth muscle cells, all of which are critical to the health of the cardiovascular system. A certain level of endoplasmic reticulum stress can help cells adapt to unfavorable conditions, but if the stress is excessive, it may impair cardiovascular function and exacerbate disease progression.
%K 内质网应激&#65292
%K 心血管疾病&#65292
%K PERK通路&#65292
%K IRE1通路&#65292
%K ATF6通路<br>Endoplasmic Reticulum Stress
%K Cardiovascular Disease
%K PERK Pathway
%K IRE1 Pathway
%K ATF6 Pathway
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=110273