%0 Journal Article %T 泛凋亡在脓毒症中的当前证据和治疗意义
Current Evidence and Therapeutic Implications of PANoptosis in Sepsis %A 王增凤 %A 单亮 %J Advances in Clinical Medicine %P 2490-2504 %@ 2161-8720 %D 2025 %I Hans Publishing %R 10.12677/acm.2025.153885 %X 脓毒症是一种严重的全身炎症反应综合征，其特征是机体对感染的免疫反应失调，导致多器官功能障碍。近年来，泛凋亡作为一种新的细胞死亡形式，在脓毒症及其并发症的发病过程中受到越来越多的关注。泛凋亡是由特定触发因素激活并由泛凋亡体复合物调节的炎症程序性细胞死亡途径，同时具有细胞焦亡、细胞凋亡和/或坏死性凋亡的关键特征。当前的研究证据表明，脓毒症患者在发病过程中会出现多种形式的程序性细胞死亡，泛凋亡是其中的重要形式。脓毒症导致的免疫细胞死亡，尤其是泛凋亡，是脓毒症免疫抑制的核心原因。一些研究还发现，泛凋亡相关组分在脓毒症患者的组织和血液中表达异常，这进一步证实了泛凋亡在脓毒症及其并发症中的重要作用。在治疗方面，针对泛凋亡的干预策略可能为脓毒症的治疗提供新的思路。通过抑制泛凋亡的关键分子或通路，可以减轻脓毒症及其并发症的病理损伤，改善患者的预后。然而，目前针对泛凋亡的治疗策略仍处于研究阶段，尚未广泛应用于临床。因此，未来的研究需要进一步深入探索泛凋亡在脓毒症中的具体作用机制，并开发针对泛凋亡的有效治疗策略。综上所述，泛凋亡在脓毒症及其并发症的发病过程中起着重要作用，其干预策略可能为脓毒症的治疗提供新的思路。未来的研究需要进一步深入探索泛凋亡的具体作用机制，并开展临床试验以验证其治疗意义。
Sepsis is a severe systemic inflammatory response syndrome characterized by the dysregulation of the body’s immune response to infection, leading to multiple organ dysfunction. In recent years, PANoptosis, as a new form of cell death, has attracted more and more attention in the pathogenesis of sepsis and its complications. PANoptosis is an inflammatory programmed cell death pathway activated by specific triggers and regulated by the PANoptotic complex, which simultaneously has the key features of pyroptosis, apoptosis, and/or necroptosis. Current research evidence suggests that patients with sepsis in the course of disease will appear a variety of forms of programmed cell death, and PANoptosis is one of the important forms. The death of immune cells, especially PANoptosis, caused by sepsis is the core cause of immunosuppression in sepsis. Some studies have also found that PANoptosis-related components are abnormally expressed in the tissues and blood of patients with sepsis, which further confirms the important role of PANoptosis in sepsis and its complications. In treatment, in view of the intervention strategy of the PANoptosis may provide a new train of thought for the treatment of sepsis. By inhibiting the key molecules or pathways of PANoptosis, the pathological damage of sepsis and its complications can be reduced and the prognosis of patients can be improved. However, current therapeutic strategies against PANoptosis are still in the research stage and have not been widely used in clinical practice. Therefore, future research is needed to further explore the specific mechanism of PANoptosis in sepsis and develop effective therapeutic strategies against PANoptosis. To sum up, the PANoptosis in the pathogenesis of sepsis and its COMPLICATIONS plays an important role in the process, its intervention strategy may provide a new train of thought for the treatment %K 脓毒症， %K 泛凋亡， %K 细胞死亡
Sepsis %K PANoptosis %K Cell Death %U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=110272