%0 Journal Article
%T 基于PI3K/Akt/mTOR通路探讨中医药治疗IgA肾病的研究进展<br>Research Progress on Traditional Chinese Medicine Treatment of IgA Nephropathy Based on PI3K/Akt/mTOR Pathway
%A 申思
%A 李丽琦
%J Traditional Chinese Medicine
%P 982-991
%@ 2166-6059
%D 2025
%I Hans Publishing
%R 10.12677/tcm.2025.143148
%X 免疫球蛋白A (IgA)肾病是最常见的原发性肾小球疾病&#65292;是导致终末期肾脏病的关键原因之一。IgA肾病发病机制十分复杂多样&#65292;磷脂酰肌醇3-激酶(PI3K)/蛋白激酶B (PKB&#65292;又称Akt)/哺乳动物雷帕霉素靶蛋白(mTOR)信号通路是细胞内一条至关重要的信号通路&#65292;与IgA肾病的发生发展密不可分。近年来&#65292;中医药在防治IgA肾病方面的研究逐渐深入&#65292;展现了中医药的独特优势。基于中医药治疗IgA肾病的现状&#65292;本文参考了近几年国内外文献&#65292;探讨了PI3K/Akt/mTOR信号通路在IgA肾病中的调控作用及中医药基于该通路对IgA肾病的作用&#65292;以期为中医药防治IgA肾病提供新思路。<br>Immunoglobulin A (IgA) nephropathy is the most common primary glomerular disease and one of the key causes of end-stage renal disease. The pathogenesis of IgA nephropathy is very complex and diverse. The phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB, also known as Akt)/mammalian rapamycin target protein (mTOR) signaling pathway is a crucial intracellular signaling pathway that is closely related to the occurrence and development of IgA nephropathy. In recent years, research on traditional Chinese medicine in the prevention and treatment of IgA nephropathy has gradually deepened, demonstrating the unique advantages of traditional Chinese medicine. Based on the current situation of traditional Chinese medicine treatment for IgA nephropathy, this article refers to recent domestic and foreign literature to explore the regulatory role of the PI3K/Akt/mTOR signaling pathway in IgA nephropathy and the effect of traditional Chinese medicine on IgA nephropathy based on this pathway, in order to provide new ideas for the prevention and treatment of IgA nephropathy with traditional Chinese medicine.
%K PI3K/Akt/mTOR&#65292
%K 信号通路&#65292
%K IgA肾病&#65292
%K 中医药&#65292
%K 研究进展<br>PI3K/Akt/mTOR
%K Signaling Pathway
%K IgA Nephropathy
%K Traditional Chinese Medicine
%K Research Progress
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=109980