%0 Journal Article
%T 尘肺与微生物相互作用与影响研究进展<br>Research Progress on Interaction and Influence between Pneumoconiosis and Microorganisms
%A 杨天文
%A 王维
%A 杜航
%J Advances in Microbiology
%P 45-51
%@ 2327-0829
%D 2025
%I Hans Publishing
%R 10.12677/amb.2025.141006
%X 尘肺病是由长期吸入粉尘引起的弥漫性肺纤维化疾病&#65292;全球范围内流行。本文综述了尘肺病与肺部微生物组的关联&#65292;揭示了尘肺患者肺部微生物多样性降低和条件致病菌丰度增加的现象&#65292;这些变化与肺部炎症和纤维化密切相关。研究显示&#65292;粉尘暴露可改变肺部微生物组成&#65292;影响免疫和炎症反应。尽管当前研究取得了进展&#65292;但仍面临样本量小和方法学差异等挑战。未来研究需开展大规模纵向研究&#65292;标准化方法学&#65292;深入探讨微生物组与宿主免疫的相互作用&#65292;为尘肺病的防治提供新策略。<br>Pneumoconiosis is a diffuse pulmonary fibrosis disease caused by long-term inhalation of dust, which is prevalent worldwide. This article reviews the association between pneumoconiosis and the lung microbiome, revealing a phenomenon of reduced lung microbial diversity and increased abundance of conditional pathogens in patients with pneumoconiosis, which is closely related to pulmonary inflammation and fibrosis. Studies show that dust exposure can alter the composition of the lung microbiota, affecting immune and inflammatory responses. Despite the progress made in current research, challenges remain, such as small sample sizes and methodological differences. Future research needs to conduct large-scale longitudinal studies, standardize methodology, and delve into the interaction between the microbiome and host immunity to provide new strategies for the prevention and treatment of pneumoconiosis.
%K 尘肺&#65292
%K 肺部微生物组&#65292
%K 肺纤维化<br>Pneumoconiosis
%K Lung Microbiome
%K Pulmonary Fibrosis
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=110072