%0 Journal Article
%T 衰老的生物标志物研究进展<br>Recent Advances in the Study of Biomarkers of Aging
%A 肖夤凡
%A 郑彬
%A 田丹丹
%A 毕建忠
%A 谢兆宏
%J Advances in Clinical Medicine
%P 2336-2348
%@ 2161-8720
%D 2025
%I Hans Publishing
%R 10.12677/acm.2025.153869
%X 衰老是一个复杂且多方面的过程&#65292;其通常被认为是生命过程中各种事件和过程所带来影响的积累过程&#65292;并将导致机体功能减退、慢性疾病&#65292;最终指向死亡。衰老的生物学研究本质在于回答三个核心问题&#65306;我们有多老&#65311;我们为什么会衰老&#65311;如何延缓衰老&#65311;而作为可被定量的生物参数&#65292;衰老的生物标志物可以衡量衰老的进程&#65292;进而帮助我们探究衰老的相关机制&#65292;最终做到干预衰老。本综述总结了衰老生物标志物研究的最新进展&#65292;从细胞、器官层面上回顾了衰老标志物的特征及它们在衰老过程中的作用机制&#65292;并讨论了利用这些标志物来开发衰老干预策略的潜力&#65292;揭示了未来衰老研究的方向及所面临的挑战。<br>Aging is a complex and multifaceted process characterized by the cumulative effects of various biological events and processes throughout the life course, ultimately resulting in diminished physiological function, chronic diseases, and eventually death. The core of biological research on aging revolves around three fundamental questions: How do we quantify age? What are the mechanisms driving aging? How can we delay or mitigate the aging process? Biomarkers of aging, as quantifiable biological parameters, provide a means to measure and understand the aging process, thereby facilitating the exploration of underlying mechanisms and enabling potential interventions. This review synthesizes recent advancements in the study of aging biomarkers, examines the characteristics and mechanisms of these markers at both cellular and organ levels, evaluates their potential for developing intervention strategies, and outlines future directions and challenges in aging research.
%K 衰老&#65292
%K 生物标志物&#65292
%K 细胞衰老<br>Aging
%K Biomarker
%K Cellular Senescence
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=110133