%0 Journal Article
%T REG Ia基因在炎症性肠病中的表达及临床意义<br>Expression of REG Ia Gene and Its Clinical Significance in Inflammatory Bowel Diseases
%A 邓思俊
%A 熊励晶
%A 刁倩
%A 陈佳佳
%J Advances in Clinical Medicine
%P 2065-2070
%@ 2161-8720
%D 2025
%I Hans Publishing
%R 10.12677/acm.2025.153838
%X 炎症性肠病(inflammatory bowel disease, IBD)是一种发病机制复杂的慢性炎症性肠道疾病&#65292;包含遗传、环境和免疫因素等相关因素。REG Ia (regenerating gene Ia)是与肠道上皮细胞修复和再生密切相关的基因。REG Ia在IBD患者肠道中表达显著上调&#65292;且其水平与IBD的严重程度呈正相关&#65292;且在治疗反应良好的患者中表达水平下降。因此&#65292;REG Ia可能作为IBD疾病活动性的生物标志物&#65292;并为IBD的个体化治疗提供潜在的分子靶点。<br>Inflammatory bowel disease (IBD) is a chronic inflammatory digestive tract disease with a complex pathogenesis, involving genetic, environmental, and immune factors, among others. Regenerating gene Ia (REG Ia) is a gene that is closely related to the repair and regeneration of intestinal epithelial cells. REG Ia is significantly upregulated in the intestines of IBD patients, and its level is positively correlated with the severity of IBD, and it decreases in patients with good treatment response. Therefore, REG Ia may serve as a biomarker for IBD disease activity and potentially provide a potential molecular target for individualized treatment of IBD.
%K 炎症性肠病&#65292
%K 人再生胰岛衍生蛋白1<i>&#945
%K </i>&#65292
%K 生物标志物<br>Inflammatory Bowel Disease
%K Human Regenerative Islet-Derived Protein 1<i>&#945
%K </i>
%K Biomarker
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=109932