%0 Journal Article
%T METTL家族与代谢性疾病调控
The METTL Family in Metabolic Disease Regulation
%A 刘一鸣
%A 周嘉强
%J Advances in Clinical Medicine
%P 2020-2030
%@ 2161-8720
%D 2025
%I Hans Publishing
%R 10.12677/acm.2025.153833
%X 随着经济和社会的发展，代谢性疾病的患病率逐年升高，已为全球带来巨大的疾病负担。甲基转移酶样蛋白(Methyltransferase-Like Proteins, METTLs)可调控表观遗传学机制，已成为近年来新兴的研究热点。文章就METTL家族调控三大代谢性疾病的分子机制作一综述，涉及调控胰岛β细胞功能、胰岛素抵抗、脂肪生成、脂质代谢、血糖稳态等多个方面。希望未来可继续进行更为广泛和深层次的研究，为多种代谢性疾病的诊疗提供理论依据。
With the advancement of socioeconomic development, the prevalence of metabolic diseases has been steadily increasing, imposing a significant disease burden globally. Methyltransferase-Like Proteins (METTLs), which regulate epigenetic mechanisms, have emerged as a burgeoning research focus in recent years. This review comprehensively summarizes the molecular mechanisms by which METTL family members regulate three major metabolic diseases, including their roles in modulating pancreatic β-cell function, insulin resistance, adipogenesis, lipid metabolism, and glucose homeostasis. We anticipate that further extensive and in-depth investigations will provide a theoretical foundation for the diagnosis and treatment of diverse metabolic disorders.
%K METTL甲基转移酶样蛋白，
%K 表观遗传学，
%K 2型糖尿病，
%K 非酒精性脂肪肝，
%K 肥胖症
Methyltransferase-Like Proteins
%K Epigenetics
%K Type 2 Diabetes Mellitus
%K Non-Alcoholic Fatty Liver Disease
%K Obesity
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=109927