%0 Journal Article %T COVID-19 Vaccine Uptake: Prevalence, Health Facility Enablers and Barriers among Adult Tuberculosis Patients across Nairobi County Clinics, Kenya %A Waqo Boru %A George Makalliwa %A Caroline Musita %J Journal of Tuberculosis Research %P 15-28 %@ 2329-8448 %D 2025 %I Scientific Research Publishing %R 10.4236/jtr.2025.131002 %X Patients with tuberculosis (TB) are at increased risk of developing severe forms of novel coronavirus 2019 (COVID-19), and COVID-19 coinfection aggravates active TB progression through immunosuppression. Despite the availability of COVID-19 vaccines to prevent and reduce COVID-19 transmission, COVID-19 vaccine uptake levels remain low worldwide. In Kenya, an African country with high TB prevalence and TB-HIV coinfection, 47% of the population had received the COVID-19 vaccine by 2023. This study determined health-system enablers and barriers to the COVID-19 vaccine among adult TB patients across Nairobi County TB clinics in Kenya. An analytical cross-sectional study was used. Three hundred eighty-eight TB patients from six TB clinics across six sub-counties in Nairobi were recruited. The participants completed the study questionnaire. After confounding for age, employment status perceived COVID-19 susceptibility, and perceived COVID-19 seriousness, health system enablers of COVID-19 vaccine uptake were consistent and positive messaging on COVID-19 (adjusted odds ratio (aOR) = 4.498; 95% CI: 1.953 - 10.36, p < 0.001), the feeling that the vaccination had significant social benefits was (aOR = 2.632; 95% CI: 1.108 - 6.257, p = 0.028), and enough public awareness about the vaccine (aOR = 2.619; 95% CI: 1.099 - 6.239, p = 0.03). A significant barrier was vaccine preference (aOR = 0.387, 95% CI: 0.179 - 0.838, p = 0.016). This study confirmed health facility factors that enable and hinder COVID-19 vaccine uptake among TB patients. We recommend policy actions to improve TB clinics’ infrastructure and resources to support the enablers and address the barriers. %K Coronavirus %K COVID-19 %K Enablers %K Barriers %K Tuberculosis %K Vaccine Uptake %U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=141405