%0 Journal Article
%T Antiviral Activity of Natural Compounds Immuno Formula Shiban2/5 against SARS-CoV-2
%A Abdulhameed Abdulridha Al Shaibani
%A Mohamed Taoubane Maallah
%A Abderahim Maallah
%J Advances in Bioscience and Biotechnology
%P 90-102
%@ 2156-8502
%D 2025
%I Scientific Research Publishing
%R 10.4236/abb.2025.163005
%X SARS-CoV-2 poses a significant risk to global healthcare systems based on the recent worldwide COVID-19 pandemic. Spike proteins are the hallmark of SARS-Cov-2, which bind to ACE2 receptors that lead to cell and membrane fusion. To address and alleviate respiratory health issues, we at Shiban Pharma have developed a range of natural products derived from plant and herb extracts, recognized for their antiviral activity against SARS-CoV-2, such as propolis extracts. In this study, we are evaluating the effects of the immuno-formula Shiban 2 and Shiban 5 (IF 2/5) on the infection of airway epithelial cells (A549) and primary airway epithelial cell (PAEC) by SARS-CoV-2. The objective is to evaluate the effects of IF 2/5 and of a placebo on viral infection. Our <i>in vitro</i> data demonstrates that IF 2/5 inhibits SARS-CoV-2 replication in a dose-dependent manner. Moreover, the compounds in IF 2/5 exhibit synergy, as determined by the Bliss method and Bliss synergy score. The Bliss synergy model was applied to explore the interaction between Propolis and Tannic Acid in modulating SARS-CoV-2 infection inhibition. Finally, our IF 2/5 also displays anti-inflammatory effects on cytokine markers IL-17A, IL-17F, and IL-8, contributing to an antiviral immunomodulatory response in the Propolis and Tannic Acid combination <i>in vitro</i>.
%K SARS-CoV-2
%K Immuno Formula Shiban 2/5
%K Natural Plant Extract
%K Immunity
%K Therapy
%K Antiviral
%K Respiratory
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=141385