%0 Journal Article
%T Profile of Patients Responding to Positive End-Expiratory Pressure and Prone Position during ARDS Related to COVID-19: A Case of the Sens Hospital
%A Chris Nsitwavibidila
%A Wilfrid Mbombo
%A Joseph Nsiala
%A Daniel Tonduangu
%A Junior Poba
%A Youssef Lutangu
%A Dominique Gizolme
%A Lionel Diyamona
%A Jean Claude Mubenga
%A Khazi Anga
%A Dan Kankonde
%A Noelly Mukuna
%A Gracia Likinda
%A Berhe Barhayiga
%J Open Journal of Internal Medicine
%P 64-78
%@ 2162-5980
%D 2025
%I Scientific Research Publishing
%R 10.4236/ojim.2025.151008
%X <b>Background</b><b>:</b> There is a paucity of data on the efficacy of ventilatory strategies in COVID-19-related ARDS. The aim of this study was to describe the effect of positive end-expiratory pressure (PEEP) and prone position (PP) on oxygenation and determine the profile of responders. <b>Methods</b><b>:</b> This was a cross-sectional study of patients admitted to the intensive care unit of the Sens Hospital with COVID-19-related ARDS who were invasively ventilated for more than 24 hours between 1 March 2020 and 2 March 2021. A good oxygenation response to PEEP and/or PP was defined as an increase in the PaO<sub>2</sub>/FiO<sub>2</sub> ratio (pre-post) of more than 20% within 4 hours after the application of these measures. <b>Results</b><b>:</b> Forty patients were recruited, 28 of whom were men. Standard ventilation allowed us to observe 3 subgroups of patients: 5 (12.5%) requiring protective ventilation with a PEP &#8804; 8 cmH<sub>2</sub>O, 5 (12.5%) requiring protective ventilation with a PEEP &gt; 8 cmH<sub>2</sub>O, and finally 30 (75%) requiring protective ventilation with a PEEP &gt; 8 cmH<sub>2</sub>O combined with PP sessions. Almost all (80%) of the patients (the majority of whom were obese) placed on PP with PEP &gt; 8 cmH<sub>2</sub>O had a good response to oxygenation. No characteristic was associated with non-response. <b>Conclusion</b><b>:</b> The use of PEEP and the use of prone position increased the PaO<sub>2</sub>/FiO<sub>2</sub> ratio in the vast majority of patients, particularly those who were obese. No characteristic was associated with non-response, so prone position can be offered to those with the indication. A high-powered study is needed to confirm this profile and assess the benefit of PP on mortality.
%K ARDS
%K COVID-19
%K Positive End-Expiratory Pressure
%K Oxygenation
%K Prone Position
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=141205