%0 Journal Article
%T 下一代益生菌的作用机制及临床应用进展
Advances in the Mechanism of Action and Clinical Application of Next-Generation Probiotics
%A 罗展豪
%A 刘晓田
%A 吴丽艳
%J Advances in Microbiology
%P 25-33
%@ 2327-0829
%D 2025
%I Hans Publishing
%R 10.12677/amb.2025.141004
%X 下一代益生菌(NGPs)作为新型微生物疗法，因其更强的肠道定植能力和多样的健康益处，正在引领健康干预领域的变革。本文系统综述了嗜黏蛋白阿克曼氏菌、长双歧杆菌1714、克里斯滕森菌和普拉氏栖粪杆菌等主要NGPs的作用机制，并探讨了NGPs在代谢性疾病、肿瘤、肠道疾病和其他疾病中的临床应用进展。研究发现，NGPs通过调节肠道微生物群落结构、增强免疫功能、改善肠道屏障完整性等多种机制，展现出对多种疾病的显著治疗潜力。例如，嗜黏蛋白阿克曼氏菌通过激活脂质氧化和胆汁酸代谢改善代谢功能障碍；长双歧杆菌1714可能通过调节神经营养因子水平减轻压力；克里斯滕森菌通过调节炎症信号通路和短链脂肪酸水平发挥抗肥胖作用；普拉氏栖粪杆菌产生丁酸盐从而发挥抗炎作用。尽管NGPs的研究取得了显著进展，但仍需通过大规模临床试验进一步验证其安全性和有效性，并结合基因编辑技术开发个性化制剂，以推动精准医疗的发展。
Next-generation probiotics (NGPs), as novel microbial therapeutics, are leading the change in the field of health interventions due to their enhanced intestinal colonisation and diverse health benefits. In this paper, we systematically review the mechanism of action of major NGPs, such as Akkermansia muciniphila, Bifidobacterium longum 1714, Christensenella minuta, and Faecalibacterium prausnitzii, and discuss the advances in the clinical application of NGPs in metabolic disorders, oncology, intestinal disorders, and other diseases. It was found that NGPs exhibit significant therapeutic potential for a wide range of diseases through a variety of mechanisms, such as regulating the structure of the intestinal microbial community, enhancing immune function, and improving the integrity of the intestinal barrier. For example, Akkermansia muciniphila improves metabolic dysfunction by activating lipid oxidation and bile acid metabolism; Bifidobacterium longum 1714 reduces stress by regulating the level of neurotrophic factors; Christensenella minuta exerts an anti-obesity effect by regulating inflammatory signalling pathways and the level of short-chain fatty acids; and Faecalibacterium prausnitzii exerts an anti-inflammatory effect by producing butyrate. Despite the significant progress in the research of NGPs, there is still a need to further validate their safety and efficacy through large-scale clinical trials and to develop personalised agents in combination with gene editing technologies to promote the development of precision medicine.
%K 下一代益生菌(NGPs)，
%K 研究进展，
%K 作用机制，
%K 临床应用
Next Generation Probiotics (NGPs)
%K Research Progress
%K Mechanism of Action
%K Clinical Applications
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=109530