%0 Journal Article
%T 肠道菌群代谢产物致阿尔茨海默病的促炎机制分析
Analysis of the Pro-Inflammatory Mechanisms of Gut Microbiota Metabolites in Inducing Alzheimer’s Disease
%A 李雪
%A 方芳
%J Journal of Clinical Personalized Medicine
%P 14-21
%@ 2334-3443
%D 2025
%I Hans Publishing
%R 10.12677/jcpm.2025.42140
%X 阿尔茨海默病(Alzheimer’s disease, AD)是老年性痴呆中最常见的类型。AD具体发病机制不明确，研究数据表明中枢和外周免疫过程在其中都起着关键作用，已证实肠道微生物群及代谢产物具有外周、中枢促炎作用。本综述主要阐述肠道菌群代谢物促炎作用致AD样病理改变，期望通过靶向调节肠道菌群改善炎症反应，达到延缓AD发生发展的目的，提高患者生活质量，减少家庭和社会的经济负担。
Alzheimer’s disease (AD) is the most common type of senile dementia. The specific pathogenesis of AD is unclear, and the research data show that both central and peripheral immune processes play a key role in it, and the intestinal microbiota and metabolites have been confirmed to have peripheral and central pro-inflammatory effects. This review mainly describes the pro-inflammatory effect of gut microbiota metabolites to cause AD-like pathological changes, hoping to improve the inflammatory response by targeting the intestinal microbiota, achieve the purpose of delaying the occurrence and development of AD, improve the quality of life of patients, and reduce the economic burden on families and society.
%K 炎症，
%K 阿尔茨海默病，
%K 肠道菌群
Inflammation
%K Alzheimer’
%K s Disease
%K Gut Microbiota
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=109151