%0 Journal Article
%T mNGS技术在下呼吸道感染精准诊断中的运用与挑战<br>The Application and Challenges of mNGS Technology in the Accurate Diagnosis of Lower Respiratory Tract Infections
%A 马祥松
%A 徐绣宇
%J Advances in Clinical Medicine
%P 189-197
%@ 2161-8720
%D 2025
%I Hans Publishing
%R 10.12677/acm.2025.152332
%X 下呼吸道感染长期以来都是全球主要导致死亡的原因之一&#65292;并且随着感染多重耐药菌患者的比例增加&#65292;快速而又准确地明确致病微生物在治疗中变得至关重要。宏基因组二代测序的出现打破了传统检测方法的局限性&#65292;它能一次性检测出标本中已知或未知的细菌、真菌及病毒&#65292;为病原微生物的检测提供了一种更全面和精准的工具。目前宏基因组二代测序已广泛运用于临床中&#65292;虽然它在使用中还面临着一些挑战和局限性&#65292;但其在感染性疾病的诊断中展现出的独特优势&#65292;使其成为一种极具潜力的技术工具。<br>Lower respiratory tract infections have long been one of the leading causes of mortality worldwide. With the increasing proportion of patients infected with multidrug-resistant pathogens, rapidly and accurately identifying causative microorganisms has become crucial in treatment. The advent of metagenomic next-generation sequencing (mNGS) has overcome the limitations of traditional detection methods, enabling the simultaneous identification of known and unknown bacteria, fungi, and viruses in a single sample, providing a more comprehensive and precise tool for pathogen detection. Currently, mNGS has been widely applied in clinical practice. Despite facing certain challenges and limitations in its implementation, its unique advantages in diagnosing infectious diseases make it an exceptionally promising technological tool.
%K 下呼吸道感染&#65292
%K 宏基因组二代测序&#65292
%K 诊断&#65292
%K 病原学<br>LRTIs
%K mNGS
%K Diagnosis
%K Pathogens
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=106843