%0 Journal Article
%T 童年虐待影响攻击行为和抑郁的共同性和特异性神经机制<br>Common and Distinct Mechanisms Underlying the Influence of Childhood Maltreatment on Depression and Aggressive Behavior
%A 李湲
%J Advances in Psychology
%P 443-456
%@ 2160-7281
%D 2025
%I Hans Publishing
%R 10.12677/ap.2025.151053
%X 尽管童年虐待被广泛认为是各种内化和外化心理障碍的跨诊断风险因素&#65292;但其背后的神经机制尚不清楚。我们猜测研究结果不一致的原因可能是童年虐待对精神病理状况的影响涉及共同和特定神经通路。本研究旨在阐明童年虐待影响抑郁和攻击行为的共同和特定的神经通路。首先&#65292;我们对静息态功能磁共振成像数据进行网络基础统计(NBS)分析&#65292;以识别与抑郁和攻击行为相关的功能连接模式。然后&#65292;进行中介分析&#65292;以评估这些功能连接模式在童年虐待与攻击、抑郁之间的关系中的作用。结果表明&#65292;默认网络内的功能连接&#65292;以及扣带盖网络和背侧注意网络之间的功能连接介导了童年虐待与攻击行为之间的关系&#65292;而奖励系统内的功能连接以及扣带盖网络与奖励系统之间的功能连接介导了童年虐待与抑郁之间的联系。因此&#65292;我们推测&#65292;控制网络可能是解释童年虐待后果的跨诊断神经机制&#65292;而注意网络和奖励网络可能分别作为将童年虐待与抑郁和攻击行为联系起来的特定神经机制。<br>Although childhood maltreatment (CM) is widely recognized as a transdiagnostic risk factor for various internalizing and externalizing psychological disorders, the neural mechanisms underlying this association remain unclear. The potential reasons for the inconsistent findings may be attributed to the involvement of both common and specific neural pathways that mediate the influence of CM on the emergence of psychopathological conditions. This study aimed to delineate both the common and distinct neural pathways linking CM to depression and aggression. First, we employed Network-Based Statistics (NBS) on resting-state functional magnetic resonance imaging (fMRI) data to identify functional connectivity (FC) patterns associated with depression and aggression. Mediation analyses were then conducted to assess the role of these FC patterns in the relationship between CM and each outcome. The results demonstrated that FC within the default mode network (DMN) and between the cingulo-opercular network (CON) and dorsal attention network (DAN) mediated the association between CM and aggression, whereas FC within the reward system and between the CON and the reward system mediated the link between CM and depression. We speculate that the control system may serve as a transdiagnostic mechanism accounting for the sequela of CM, and the attention network and the reward network may act as specific mechanisms linking CM to depression and aggression, respectively.
%K 童年虐待&#65292
%K 抑郁&#65292
%K 攻击行为&#65292
%K 控制系统&#65292
%K 注意网络&#65292
%K 奖励网络<br>Childhood Maltreatment
%K Depression
%K Aggressive Behavior
%K Control System
%K Attention Network
%K Reward System
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=106634