%0 Journal Article
%T <i>Guiera</i> <i>senegalensis</i> Alleviates Ischemia Renal Reperfusion Injury in Albinos Wistar Rats
%A Mama Sy
%A Fatoumata Bah
%A Mouhamed Ch&#233
%A rif Dial
%A Robert Foko
%A Racha Kamenda Ibondou
%A Cheikh Diop
%A Abdoulaye S&#233
%A ga Diallo
%J Open Journal of Pathology
%P 16-27
%@ 2164-6783
%D 2025
%I Scientific Research Publishing
%R 10.4236/ojpathology.2025.151002
%X <b>Introduction: </b>Renal ischemia-reperfusion (IR) is responsible for injuries such as destruction or dysfunction of tubular epithelial cells with inflammatory reaction and oxidative stress. Several therapeutic methods have been tested to alleviate ischemia-perfusion injury, ranging from using anti-inflammatory drugs, antioxidants, and plants from traditional pharmacopeia to administering RNA interference. However, there is currently no effective therapeutic option available for the treatment of renal IR injury, other than supportive therapies such as renal replacement therapy or hydration. <b>Objective: </b>This present study aimed to evaluate the effect of <i>Guiera</i> <i>senegalensis</i> on renal ischemia reperfusion, a recognized plant for its antioxidant and anti-inflammatory properties. <b>Materials and </b><b>Methods</b><b>:</b> Twenty-four (24) adult male Wistar rats were divided into four following groups: SLAM (subjected to a median laparotomy with simulated ischemia); GUIERRA (animals that received 250 mg/kg of guierra senegalensis orally, once a day, for 5 days, with simulated renal ischemia); IR (animals that underwent laparotomy followed by clamping of bilateral renal pedicles for 45 min and followed by reperfusion); GUIERRA + IR (animals given GUIERRA at the dosage of 250 mg/kg per day, for 5 days and then subjected to renal ischemia-reperfusion). Data analysis was performed by ANOVA, and a significance level of p &lt; 0.05 was chosen. Blood and renal tissue samples from all rats were collected after 24 h. Histopathological analysis of the kidneys was performed by evaluating the degree of tubular degeneration, the presence of interstitial lymphocytic infiltrate, proteinaceous casts, necrosis, and loss of the brush border appearance of the tubules using a dedicated score. In the blood samples, creatinine levels were evaluated. <b>Results:</b> Compared with the I/R group, rats in the GUIERRA + IR group showed reduced histopathological damage scores (p &lt; 0.05). Although the differences in creatinine levels were not statistically significant, these were significantly decreased in the treatment group. <b>Conclusion: </b>The results of this preliminary work suggest that <i>Guiera</i> <i>senegalensis</i> decreases the degree of tissue damage in renal ischemia-reperfusion cases. This plant seems to be a promising therapeutic; further studies could help to precise the targets of its compounds on ischemia-reperfusion pathways.
%K Ischemia Reperfusion
%K Acute Kidney Injury
%K <i>Guiera</i> <i>senegalensis</i>
%K Tubular Degenerescence
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=140247