%0 Journal Article
%T Intraperitoneal Instillation of Dexmedetomidine vs Dexamethasone as Adjuvant to Bupivacaine for Postoperative Pain in Laparoscopic Cholecystectomy, a Randomized Clinical Trial
%A Ayman Mohamady Eldemrdash
%A Zaher Z. Zaher
%A Tarek S. Hemaida
%A Taha T. Dardeer
%A Hani M. Raslan
%A Shawky M. Abdelgalil
%A Mohmed R. Saad
%A Mohammed S. Aly
%J Open Journal of Anesthesiology
%P 1-12
%@ 2164-5558
%D 2025
%I Scientific Research Publishing
%R 10.4236/ojanes.2025.151001
%X <b>Background:</b> Intraperitoneal instillation (IPI) of local anesthesia was reported to reduce postoperative pain after laparoscopic surgeries. We aim to evaluate the effectiveness of IPI of bupivacaine + dexmedetomidine versus bupivacaine + dexamethasone on postoperative pain in patients undergoing laparoscopic cholecystectomy (LC). <b>Methods:</b> This randomized clinical trial was carried out on one hundred patients who underwent LC under general anesthesia. Patients were randomly divided into: <b>Group (</b><b>Dexa</b><b>):</b> IPI of bupivacaine with dexamethasone and <b>Group (</b><b>Dexmed</b><b>):</b> IPI of bupivacaine with dexmedetomidine. <b>Results: </b>The first time to request analgesia was significantly delayed in the dexmed group (P value &lt; 0.001). The total analgesic consumption in the 1st postoperative day significantly increased considerably when using IPI of dexmedetomidine as an adjuvant to Bupivacaine (P value &lt; 0.001). VAS, HR, and MAP at 2 h postoperative were statistically but not clinically significantly higher in the dexamethasone group (P value &lt; 0.001), while there were no significant differences at 1, 4, 8, 16, and 24 h postoperative. <b>Conclusions: </b>Intraperitoneal Bupivacaine + Dexmedetomidine provided longer pain-free postoperative duration lower pain score over time, and lesser analgesic consumption.
%K Bupivacaine
%K Dexmedetomidine
%K Dexamethasone
%K Laparoscopic Cholecystectomy
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=140148