%0 Journal Article
%T 基于PI3K/Akt/mTOR信号通路探讨中医药治疗多囊卵巢综合征的研究进展<br>Research Progress on Traditional Chinese Medicine Treatment of Polycystic Ovary Syndrome Based on the PI3K/Akt/mTOR Signaling Pathway
%A 陈梦晴
%A 张锐
%A 李家瑜
%A 匡洪影
%J Traditional Chinese Medicine
%P 184-193
%@ 2166-6059
%D 2025
%I Hans Publishing
%R 10.12677/tcm.2025.141029
%X 多囊卵巢综合征(PCOS)因其病因复杂&#65292;症状繁多&#65292;严重影响女性的身心健康&#65292;然而其发病机制尚未阐明。近年来越来越多的研究证实&#65292;细胞自噬和凋亡在PCOS的发生发展中起关键作用&#65292;且自噬与PCOS相关的代谢异常&#65292;如胰岛素抵抗(IR)密切相关。PI3K/Akt/mTOR信号通路是经典的自噬信号通路。基于目前中医药治疗PCOS的研究现状&#65292;本文就PI3K/Akt/mTOR信号通路在PCOS中的作用机制及中医药通过调控该通路治疗PCOS的研究进展进行综述&#65292;为PCOS的防治提供新思路。<br>Polycystic ovary syndrome (PCOS), due to its complex etiology and numerous symptoms, seriously affects the physical and mental health of women. However, its pathogenesis has not yet been elucidated. In recent years, more and more studies have confirmed that autophagy and apoptosis play a crucial role in the occurrence and development of PCOS, and autophagy is closely related to metabolic abnormalities related to PCOS, such as insulin resistance (IR). The PI3K/Akt/mTOR signaling pathway is a classic autophagy signaling pathway. Based on the current research status of traditional Chinese medicine in the treatment of PCOS, this article reviews the mechanism of PI3K/Akt/mTOR signaling pathway in PCOS and the research progress of traditional Chinese medicine in regulating this pathway to treat PCOS, providing new ideas for the prevention and treatment of PCOS.
%K 多囊卵巢综合征&#65292
%K PI3K/Akt/mTOR信号通路&#65292
%K 自噬&#65292
%K 凋亡&#65292
%K 胰岛素抵抗<br>Polycystic Ovary Syndrome
%K PI3K/Akt/mTOR Signaling Pathway
%K Autophagy
%K Apoptosis
%K Insulin Resistance
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=105434