%0 Journal Article
%T O-GlcNAc糖基化修饰在癌症中的调控机制<br>The Regulatory Mechanism of O-GlcNAc Glycosylation Modification in Cancer
%A 周美欣
%A 刘桐
%A 薛娟
%J Advances in Clinical Medicine
%P 947-953
%@ 2161-8720
%D 2025
%I Hans Publishing
%R 10.12677/acm.2025.151126
%X O-GlcNAc糖基化是一种可逆的蛋白质翻译后修饰。O-GlcNAc循环失衡在癌症的发生和发展中起着至关重要的作用。因此&#65292;探索O-GlcNAc糖基化与肿瘤之间的作用机制对于开发新的靶向治疗方法具有极其重要的意义。本文阐明O-GlcNAc糖基化修饰使细胞能够将营养物质的可用性和细胞代谢与关键细胞过程调节联系起来&#65292;其中许多可能在癌症中受到损害。总结O-GlcNAc糖基化调节在肿瘤治疗中的作用&#65292;为临床实践中开发新的靶向疗法提供了理论依据。<br>O-GlcNAc glycosylation is a reversible post-translational modification of proteins. The imbalance of O-GlcNAc cycle plays a crucial role in the occurrence and development of cancer. Therefore, exploring the mechanism of action between O-GlcNAc glycosylation and tumors is of great significance for developing new targeted therapies. This article elucidates that O-GlcNAc glycosylation modification enables cells to link the availability of nutrients and cellular metabolism with the regulation of key cellular processes, many of which may be compromised in cancer. Summarizing the role of O-GlcNAc glycosylation regulation in tumor therapy provides a theoretical basis for the development of new targeted therapies in clinical practice.
%K O-GlcNA糖基化&#65292
%K 分子机制&#65292
%K 预后<br>O-GlcNA Glycosylation
%K Molecular Mechanism
%K Prognosis
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=105399