%0 Journal Article
%T T淋巴细胞亚群在NAFLD发病机制中的作用
The Roles of T Lymphocyte Subsets in the Pathogenesis of NAFLD
%A 许琳
%A 高韬
%A 柯大智
%J Advances in Clinical Medicine
%P 777-786
%@ 2161-8720
%D 2025
%I Hans Publishing
%R 10.12677/acm.2025.151105
%X 非酒精性脂肪性肝病(Non-alcoholic fatty liver disease, NAFLD)包括一系列的肝脏表现，从肝脏脂肪变性开始，可能演变为非酒精性脂肪性肝炎(Non-alcoholic steatohepatitis, NASH)、纤维化、肝硬化甚至肝细胞癌(Hepatocellular carcinoma, HCC)。其发病率在全球范围内呈上升趋势。尽管NAFLD是一种与代谢紊乱相关的疾病，但它也涉及多种免疫细胞介导的炎症过程。多种免疫细胞通过分泌促炎或抗炎因子来促进或抑制肝细胞炎症，从而影响NAFLD进程。T细胞作为适应性免疫中重要的一环，包括多种淋巴细胞亚群，在NAFLD的进展中发挥着关键作用。本文综述了T淋巴细胞亚群在NAFLD发病机制中的作用，以期为非酒精性脂肪性肝病的药物干预提供新策略。
Non-alcoholic fatty liver disease (NAFLD) encompasses a series of liver manifestations. Starting from hepatic steatosis, it may progress to non-alcoholic steatohepatitis (NASH), fibrosis, liver cirrhosis and even hepatocellular carcinoma (HCC). The incidence of NAFLD is on the rise globally. Although NAFLD is a disease concerning metabolic disorders, it also involves various inflammatory processes mediated by immune cells. Various immune cells promote or inhibit liver cell inflammation by secreting pro-inflammatory or anti-inflammatory factors to influence the progression of non-alcoholic fatty liver disease (NAFLD). T cells, as an important part of adaptive immunity, include multiple lymphocyte subsets and play a crucial role in the progression of NAFLD. We review the roles of T lymphocyte subsets in the pathogenesis of NAFLD, expecting to provide new strategies for the pharmaceutical intervention of non-alcoholic fatty liver disease.
%K 非酒精性脂肪性肝病(NAFLD)，
%K 非酒精性脂肪性肝炎(NASH)，
%K 肝细胞癌(HCC)，
%K CD4+T细胞，
%K CD8+T细胞；
%K γ
%K δ
%K T细胞
Non-Alcoholic Fatty Liver Disease (NAFLD)
%K Non-Alcoholic Steatohepatitis (NASH)
%K Hepatocellular Carcinoma (HCC)
%K CD4+T Cells
%K CD8+T Cells
%K γ
%K δ
%K T Cells
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=105269